Dopamine Neuron Activity and Stress Signaling as Links Between Social Hierarchy and Psychopathology Vulnerability.

Autor: Battivelli D; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Vernochet C; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Conabady E; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Nguyen C; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France; Neurophysiology and Behavior group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Paris, France., Zayed A; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Lebel A; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Meirsman AC; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Messaoudene S; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Fieggen A; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Dreux G; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Rigoni D; Université Côte d'Azur, Nice, France; Institut de Pharmacologie Moléculaire and Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7275, Valbonne, France., Le Borgne T; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France; Neurophysiology and Behavior group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Paris, France., Marti F; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France; Neurophysiology and Behavior group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Paris, France., Contesse T; Université Côte d'Azur, Nice, France; Institut de Pharmacologie Moléculaire and Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7275, Valbonne, France., Barik J; Université Côte d'Azur, Nice, France; Institut de Pharmacologie Moléculaire and Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7275, Valbonne, France., Tassin JP; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France., Faure P; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France; Neurophysiology and Behavior group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Paris, France., Parnaudeau S; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France. Electronic address: sebastien.parnaudeau@sorbonne-universite.fr., Tronche F; Gene Regulation and Adaptive Behaviors group, Department of Neuroscience Paris Seine, Unité Mixte de Recherche 8246, Centre National de la Recherche Scientifique, Institut de Biologie Paris Seine, Paris, France; Institut National de la Santé et de la Recherche Médicale U1130, Paris, France; Sorbonne Université, Paris, France. Electronic address: francois.tronche@sorbonne-universite.fr.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2024 Apr 15; Vol. 95 (8), pp. 774-784. Date of Electronic Publication: 2023 Oct 05.
DOI: 10.1016/j.biopsych.2023.08.029
Abstrakt: Background: Social status in humans, generally reflected by socioeconomic status, has been associated, when constrained, with heightened vulnerability to pathologies including psychiatric diseases. Social hierarchy in mice translates into individual and interdependent behavioral strategies of animals within a group. The rules leading to the emergence of a social organization are elusive, and detangling the contribution of social status from other factors, whether environmental or genetic, to normal and pathological behaviors remains challenging.
Methods: We investigated the mechanisms shaping the emergence of a social hierarchy in isogenic C57BL/6 mice raised in groups of 4 using conditional mutant mouse models and chemogenetic manipulation of dopamine midbrain neuronal activity. We further studied the evolution of behavioral traits and the vulnerability to psychopathological-like phenotypes according to the social status of the animals.
Results: Higher sociability predetermined higher social hierarchy in the colony. Upon hierarchy establishment, higher-ranked mice showed increased anxiety and better cognitive abilities in a working memory task. Strikingly, the higher-ranked mice displayed a reduced activity of dopaminergic neurons within the ventral tegmental area, paired with a decreased behavioral response to cocaine and a decreased vulnerability to depressive-like behaviors following repeated social defeats. The pharmacogenetic inhibition of this neuronal population and the genetic inactivation of glucocorticoid receptor signaling in dopamine-sensing brain areas that resulted in decreased dopaminergic activity promoted accession to higher social ranks.
Conclusions: Dopamine activity and its modulation by the stress response shapes social organization in mice, potentially linking interindividual and social status differences in vulnerability to psychopathologies.
(Copyright © 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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