Optically stimulated luminescence system as an alternative for radiochromic film for 2D reference dosimetry in UHDR electron beams.

Autor: Vanreusel V; Research in Dosimetric Applications, SCK CEN, Boeretang 200, 2400 Mol, Belgium; CORE, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Iridium Netwerk, Oosterveldlaan 22, 2610 Wilrijk, Belgium. Electronic address: verdi.vanreusel@sckcen.be., Gasparini A; CORE, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Iridium Netwerk, Oosterveldlaan 22, 2610 Wilrijk, Belgium., Galante F; Sordina IORT Technologies S.p.A., Via dell'Industria, 1/A, 04011 Aprilia, Latina, Italy., Mariani G; Sordina IORT Technologies S.p.A., Via dell'Industria, 1/A, 04011 Aprilia, Latina, Italy., Pacitti M; Sordina IORT Technologies S.p.A., Via dell'Industria, 1/A, 04011 Aprilia, Latina, Italy., Colijn A; CORE, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Reniers B; NuTeC, CMK, Hasselt University, Wetenschapspark 27, 3590 Diepenbeek, Belgium., Yalvac B; NuTeC, CMK, Hasselt University, Wetenschapspark 27, 3590 Diepenbeek, Belgium., Vandenbroucke D; Agfa N.V., Septestraat 27, 2640 Mortsel, Belgium., Peeters M; UZA, Edegem, Belgium., Leblans P; Agfa N.V., Septestraat 27, 2640 Mortsel, Belgium., Felici G; Sordina IORT Technologies S.p.A., Via dell'Industria, 1/A, 04011 Aprilia, Latina, Italy., Verellen D; CORE, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Iridium Netwerk, Oosterveldlaan 22, 2610 Wilrijk, Belgium., de Freitas Nascimento L; Research in Dosimetric Applications, SCK CEN, Boeretang 200, 2400 Mol, Belgium.
Jazyk: angličtina
Zdroj: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2023 Oct; Vol. 114, pp. 103147. Date of Electronic Publication: 2023 Oct 05.
DOI: 10.1016/j.ejmp.2023.103147
Abstrakt: Radiotherapy is part of the treatment of over 50% of cancer patients. Its efficacy is limited by the radiotoxicity to the healthy tissue. FLASH-RT is based on the biological effect that ultra-high dose rates (UHDR) and very short treatment times strongly reduce normal tissue toxicity, while preserving the anti-tumoral effect. Despite many positive preclinical results, the translation of FLASH-RT to the clinic is hampered by the lack of accurate dosimetry for UHDR beams. To date radiochromic film is commonly used for dose assessment but has the drawback of lengthy and cumbersome read out procedures. In this work, we investigate the equivalence of a 2D OSL system to radiochromic film dosimetry in terms of dose rate independency. The comparison of both systems was done using the ElectronFlash linac. We investigated the dose rate dependence by variation of the (1) modality, (2) pulse repetition frequency, (3) pulse length and (4) source to surface distance. Additionally, we compared the 2D characteristics by field size measurements. The OSL calibration showed transferable between conventional and UHDR modality. Both systems are equally independent of average dose rate, pulse length and instantaneous dose rate. The OSL system showed equivalent in field size determination within 3 sigma. We show the promising nature of the 2D OSL system to serve as alternative for radiochromic film in UHDR electron beams. However, more in depth characterization is needed to assess its full potential.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Two of the co-authors are employees of AGFA N.V..
(Copyright © 2023 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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