Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality.

Autor: Tegegne BS; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Said MA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ani A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., van Roon AM; Department of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Shah S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.; Institute of Cardiovascular Science, University College London, London, UK., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van der Harst P; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Riese H; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. h.snieder@umcg.nl.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2023 Oct 06; Vol. 6 (1), pp. 1013. Date of Electronic Publication: 2023 Oct 06.
DOI: 10.1038/s42003-023-05376-y
Abstrakt: Low heart rate variability (HRV) has been widely reported as a predictor for increased mortality. However, the molecular mechanisms are poorly understood. Therefore, this study aimed to identify novel genetic loci associated with HRV and assess the association of phenotypic HRV and genetically predicted HRV with mortality. In a GWAS of 46,075 European ancestry individuals from UK biobank, we identified 17 independent genome-wide significant genetic variants in 16 loci associated with HRV traits. Notably, eight of these loci (RNF220, GNB4, LINCR-002, KLHL3/HNRNPA0, CHRM2, KCNJ5, MED13L, and C160rf72) have not been reported previously. In a prospective phenotypic relationship between HRV and mortality during a median follow-up of seven years, individuals with lower HRV had higher risk of dying from any cause. Genetically predicted HRV, as determined by the genetic risk scores, was not associated with mortality. To the best of our knowledge, the findings provide novel biological insights into the mechanisms underlying HRV. These results also underline the role of the cardiac autonomic nervous system, as indexed by HRV, in predicting mortality.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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