ERS/ESTS/ESTRO/ESR/ESTI/EFOMP statement on management of incidental findings from low dose CT screening for lung cancer.

Autor:	O'Dowd EL; Nottingham University Hospitals NHS Trust, Nottingham, UK.; University of Nottingham, Faculty of Medicine and Health Sciences, Nottingham, UK., Tietzova I; Charles University, First Faculty of Medicine, Department of Tuberculosis and Respiratory Diseases, Prague, Czech Republic., Bartlett E; Royal Brompton and Harefield NHS Foundation Trust, Radiology, London, UK., Devaraj A; Royal Brompton and Harefield NHS Foundation Trust, Radiology, London, UK., Biederer J; University of Heidelberg, Diagnostic and Interventional Radiology, Heidelberg, Germany.; German Center for Lung Research DZL, Translational Lung Research Center TLRC, Heidelberg, Germany.; University of Latvia, Faculty of Medicine, Riga, Latvia.; Christian-Albrechts-Universität zu Kiel, Faculty of Medicine, Kiel, Germany., Brambilla M; Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara, Novara, Italy., Brunelli A; St. James's University Hospital, Department of Thoracic Surgery, Leeds, UK., Chorostowska-Wynimko J; Institute of Tuberculosis and Lung Diseases, Warsaw, Genetics and Clinical Immunology, Warsaw, Poland., Decaluwe H; University Hospitals Leuven, Thoracic Surgery, Leuven, Belgium., Deruysscher D; Maastricht University Medical Centre, Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Limburg, The Netherlands., De Wever W; Universitaire Ziekenhuizen Leuven, Radiology, Leuven, Belgium., Donoghue M; Galway Clinic Doughiska, Galway, Ireland., Fabre A; University College Dublin School of Medicine, Histopathology, Dublin, Ireland., Gaga M; Sotiria General Hospital of Chest Diseases of Athens, 7th Respiratory Medicine Department, Athens, Greece., van Geffen W; Medical Centre Leeuwarden, Department of Respiratory Medicine, Leeuwarden, The Netherlands.; University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands., Hardavella G; Sotiria General Hospital of Chest Diseases of Athens, Respiratory Medicine, Athens, Greece., Kauczor HU; University of Heidelberg, Diagnostic and Interventional Radiology, Heidelberg, Germany.; German Center for Lung Research DZL, Translational Lung Research Center TLRC, Heidelberg, Germany., Kerpel-Fronius A; National Koranyi Institute of Pulmonology, Department of Radiology, Budapest, Hungary., van Meerbeeck J; UZ Antwerpen, MOCA, Edegem, Belgium., Nagavci B; Institute for Evidence in Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Nestle U; Kliniken Maria Hilf GmbH Monchengladbach, Nordrhein-Westfalen, Germany., Novoa N; University Hospital of Salamanca, Thoracic Surgery, Salamanca, Spain., Prosch H; Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria., Prokop M; Radboud University Nijmegen Medical Center, Department of Radiology, Nijmegen, The Netherlands., Putora PM; Kantonsspital Sankt Gallen, Radiation Oncology, Sankt Gallen, Switzerland.; Inselspital Universitatsspital Bern, Radiation Oncology, Bern, Switzerland., Rawlinson J; European Lung Foundation, Tipton, UK., Revel MP; Cochin Hospital, APHP, Radiology Department, Paris, France.; Université de Paris, Paris, France., Snoeckx A; University Hospital Antwerp, Radiology, Edegem, Belgium., Veronesi G; Humanitas Research Hospital, Division of Thoracic and General Surgery, Rozzano, Italy., Vliegenthart R; UMCG, Groningen, The Netherlands., Weckbach S; UniversitatsKlinikum Heidelberg, Heidelberg, Germany.; Bayer AG, Research and Development, Pharmaceuticals, Radiology, Berlin, Germany., Blum TG; HELIOS Klinikum Emil von Behring GmbH, Lungenklinik Heckeshorn, Berlin, Germany., Baldwin DR; Nottingham University Hospitals NHS Trust, Nottingham, UK david.baldwin@nottingham.ac.uk.; University of Nottingham, Faculty of Medicine and Health Sciences, Nottingham, UK.
Jazyk:	angličtina
Zdroj:	The European respiratory journal [Eur Respir J] 2023 Oct 19; Vol. 62 (4). Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).
DOI:	10.1183/13993003.00533-2023
Abstrakt:	Background: Screening for lung cancer with low radiation dose computed tomography has a strong evidence base, is being introduced in several European countries and is recommended as a new targeted cancer screening programme. The imperative now is to ensure that implementation follows an evidence-based process that will ensure clinical and cost effectiveness. This European Respiratory Society (ERS) task force was formed to provide an expert consensus for the management of incidental findings which can be adapted and followed during implementation. Methods: A multi-European society collaborative group was convened. 23 topics were identified, primarily from an ERS statement on lung cancer screening, and a systematic review of the literature was conducted according to ERS standards. Initial review of abstracts was completed and full text was provided to members of the group for each topic. Sections were edited and the final document approved by all members and the ERS Science Council. Results: Nine topics considered most important and frequent were reviewed as standalone topics (interstitial lung abnormalities, emphysema, bronchiectasis, consolidation, coronary calcification, aortic valve disease, mediastinal mass, mediastinal lymph nodes and thyroid abnormalities). Other topics considered of lower importance or infrequent were grouped into generic categories, suitable for general statements. Conclusions: This European collaborative group has produced an incidental findings statement that can be followed during lung cancer screening. It will ensure that an evidence-based approach is used for reporting and managing incidental findings, which will mean that harms are minimised and any programme is as cost-effective as possible. Competing Interests: Conflict of interest: All declarations are outside the submitted work. Unless otherwise stated, authors do not make any relevant disclosures. A. Brunelli declares honoraria from AstraZeneca, Ethicon, Medtronic, MSD and Roche. J. Chorostowska declares honoraria from AstraZeneca, MSD, Pfizer, Takeda, Amgen, Grifols, CSL Behring, Novartis, Chiesi, Celon Pharma, Adamed and Mero Biopharma. A. Devaraj declares consulting fees from Boehringer Ingelheim, Roche, Vicore and Brainomix, and personal stock/options in Brainomix. D. Deruysscher declares grants/honoraria from AstraZeneca, BMS, Beigne and Philips. H. Prosch declares grants and honoraria from Boehringer Ingelheim, AstraZeneca, Siemens and MSD. A. Kerpel-Fronius declares honoraria from MSD and Boehringer Ingelheim, and conference expenses from Roche and Bracco. W. van Geffen is local PI for trials funded by MSD and Roche. H-U. Kauczor declares honoraria and grants from Boehringer Ingelheim, Philips, Siemens and MSD, and honoraria from Sanofi. P.M. Putora declares grants to his institution from AstraZeneca and Bayer. M-P. Revel declares honoraria from MSD, Boehringer Ingelheim, GE Healthcare, Bracco and Gleamer, grants from the French Ministry of Health and French Cancer Institute, and software from Aidence, Mevis, Coreline and Gleamer. R. Vliegenthart declares honoraria from Siemens Healthineers and Bayer, and research grants from the Dutch Cancer Foundation, Siemens Heathineers, the Dutch Heart Foundation and the Netherlands Organisation for Scientific Research. A. Snoeckx declares grants from the Foundation Agaist Cancer and the Flemish Cancer Society, and advisory board work for Agfa. G. Veronesi declares honoraria from AstraZeneca, Medtronic and Roche, and grants from INAIL and IARC. D.R. Baldwin declares honoraria for speaking from Roche, MSD and AstraZeneca, and research grants from CRUK, NIHR, Innovate UK, Small Business Research Initiative, NHS Digital, NHS England, Roy Castle Lung Foundation, European Commission Horizon and Yourshire Cancer; and is advisor to the UK National Screening Committee. (This article has been co-published with permission in the European Journal of Cardio-Thoracic Surgery and in the European Respiratory Journal. Copyright © The authors 2023. Published by the European Respiratory Society. All rights reserved. For reproduction rights and permissions contact permissions@ersnet.org. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. Either citation can be used when citing this article.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu