The effect of low dose thyroid replacement therapy in patients with episodic migraine and subclinical hypothyroidism: A randomised placebo-controlled trial.

Autor: Dev P; Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India., Favas TT; Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India., Jaiswal R; Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India., Cyriac M; Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India., Mishra VN; Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India., Pathak A; Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
Jazyk: angličtina
Zdroj: Cephalalgia : an international journal of headache [Cephalalgia] 2023 Oct; Vol. 43 (10), pp. 3331024231182684.
DOI: 10.1177/03331024231182684
Abstrakt: Introduction: Migraine is a common headache syndrome associated with various other comorbidities. Thyroid replacement in migraine patients with hypothyroidism improves headaches; however, thyroid hormone replacement in subclinical hypothyroidism is debatable, and its efficacy is not known.
Objective and Methodology: This prospective, single-centre, quasi-randomised interventional study was conducted on patients visiting the General Medicine and Neurology outpatient department at a tertiary centre to look at the efficacy of thyroxine in subclinical hypothyroidism.
Results: We assessed 87 patients for analysis; no patients were lost to follow-up. There was a decrease in all parameters evaluated (headache frequency, severity, duration, MIDAS score, MIDAS grade) at three months of follow-up in the treatment group compared to placebo group. There was a significant decrease in headache frequency and severity in the levothyroxine group compared to the placebo group at three months of follow-up. Also, the follow-up MIDAS score (mean ± SD: 6.30 ± 2.455 scores vs. 8.45 ± 5.757 scores) was significantly decreased by treatment at three months follow-up.
Conclusion: Treatment of subclinical hypothyroidism effectively reduces migraine headaches, and it is logical to check thyroid function status in patients presenting with migraine headaches. However, a larger randomised controlled trial is required to prove the efficacy of levothyroxine in migraine with subclinical hypothyroidism.
Competing Interests: Declaration of conflicting interestsThe authors do not have any conflict of interest to disclose in terms of research, authorship, and/or publication of this article.
Databáze: MEDLINE
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