Involvement of the serotoninergic system in the anxiolytic action mechanism of a liposomal formulation containing nimodipine (NMD-Lipo).

Autor: Viana HKMMC; Laboratory of Pharmaceutical Nanosystems (NANOSFAR), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI 64.049-550,Brazil., da Silva Oliveira GL; Laboratory of Experimental Neurochemistry (LAPNEX), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI 64.049-550,Brazil., Moreno LCGEAI; Laboratory of Pharmaceutical Nanosystems (NANOSFAR), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI 64.049-550,Brazil., de Melo-Cavalcante AAC; Laboratory of Experimental Neurochemistry (LAPNEX), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI 64.049-550,Brazil., de Moura do Amaral MP; Interdisciplinary Neuroscience and Toxicology Laboratory (LINT), PostgraduateProgram in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI 64.049-550, Brazil., Arcanjo DDR; Interdisciplinary Neuroscience and Toxicology Laboratory (LINT), PostgraduateProgram in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI 64.049-550, Brazil., Rolim HML; Laboratory of Pharmaceutical Nanosystems (NANOSFAR), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI 64.049-550,Brazil. Electronic address: hercilia.rolim@gmail.com.
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2023 Nov; Vol. 232, pp. 173654. Date of Electronic Publication: 2023 Oct 05.
DOI: 10.1016/j.pbb.2023.173654
Abstrakt: In the search for anxiolytic drugs with fewer adverse effects, calcium blockers were proposed as a benzodiazepines (BZDs) alternative. In this context, the anxiolytic effect of nimodipine has been demonstrated. However, its low bioavailability and solubility could be improved by using nanostructured drug delivery systems such as liposomes. In this way, liposomal formulation containing nimodipine (NMD-Lipo) was developed. The NMD-lipo is a formulation capable of improving the kinetic characteristics of the drug, as well as the anxiolytic effect of nimodipine. In this work, the serotonergic system participation in the anxiolytic mechanism of the liposomal formulation containing nimodipine (NMD-Lipo) was investigated. A possible 5-HT1A receptor mediation on the NMD-Lipo anxiolytic effect was demonstrated by using WAY 100635 (5-HT1A receptor antagonist) since the antagonist reversed the NMD-Lipo anxiolytic effect in the light/dark test and elevated plus maze test. The results demonstrated that the NMD-Lipo administration had anxiolytic activity through 5-HT1A receptors without causing sedation or compromising the motor coordination of the tested animals.
Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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