Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail ( Coturnix c. japonica ).

Autor:	Carnaccini S; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA., Cáceres CJ; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA., Gay LC; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA., Ferreri LM; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA., Skepner E; Center for Pathogen Evolution, University of Cambridge , Cambridge, United Kingdom., Burke DF; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, United Kingdom., Brown IH; Animal and Plant Health Agency (APHA) , Weybridge, United Kingdom., Geiger G; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA., Obadan A; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA., Rajao DS; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA., Lewis NS; World Influenza Centre, The Francis Crick Institute , London, United Kingdom., Perez DR; Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2023 Oct 31; Vol. 97 (10), pp. e0074323. Date of Electronic Publication: 2023 Oct 06.
DOI:	10.1128/jvi.00743-23
Abstrakt:	Importance: Determining the relevant amino acids involved in antigenic drift on the surface protein hemagglutinin (HA) is critical to understand influenza virus evolution and efficient assessment of vaccine strains relative to current circulating strains. We used antigenic cartography to generate an antigenic map of the H9 hemagglutinin (HA) using sera produced in one of the most relevant minor poultry species, Japanese quail. Key antigenic positions were identified and tested to confirm their impact on the antigenic profile. This work provides a better understanding of the antigenic diversity of the H9 HA as it relates to reactivity to quail sera and will facilitate a rational approach for selecting more efficacious vaccines against poultry-origin H9 influenza viruses in minor poultry species. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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