Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans.

Autor: Abdolahi F; Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Yu V; Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Varma R; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, USA., Zhou X; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Wang RK; Department of Bioengineering, University of Washington, Seattle, Washington, USA.; Department of Ophthalmology, University of Washington, Seattle, Washington, USA., D'Orazio LM; Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Zhao C; Laboratory of FMRI Technology, Stevens Neuroimaging and Informatics Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Jann K; Laboratory of FMRI Technology, Stevens Neuroimaging and Informatics Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Wang DJ; Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.; Laboratory of FMRI Technology, Stevens Neuroimaging and Informatics Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Kashani AH; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jiang X; Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Feb; Vol. 20 (2), pp. 858-868. Date of Electronic Publication: 2023 Oct 06.
DOI: 10.1002/alz.13469
Abstrakt: Introduction: We investigated whether retinal capillary perfusion is a biomarker of cerebral small vessel disease and impaired cognition among Black Americans, an understudied group at higher risk for dementia.
Methods: We enrolled 96 Black Americans without known cognitive impairment. Four retinal perfusion measures were derived using optical coherence tomography angiography. Neurocognitive assessment and brain magnetic resonance imaging (MRI) were performed. Multiple linear regression analyses were performed.
Results: Lower retinal capillary perfusion was correlated with worse Oral Symbol Digit Test (P < = 0.005) and Fluid Cognition Composite scores (P < = 0.02), but not with the Crystallized Cognition Composite score (P > = 0.41). Lower retinal perfusion was also correlated with higher free water and peak width of skeletonized mean diffusivity, and lower fractional anisotropy (all P < 0.05) on MRI (N = 35).
Discussion: Lower retinal capillary perfusion is associated with worse information processing, fluid cognition, and MRI biomarkers of cerebral small vessel disease, but is not related to crystallized cognition.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
Externí odkaz: