Doxycycline for Multidrug-Resistant Gram-Negative Bacterial Infection Treatment: A Scoping Review.
| Autor: | de Macedo V; Department of Infectious Diseases, Hospital Infection Control and Epidemiology Center, Santa Casa de Curitiba, Curitiba, Paraná, Brazil., Meneghete BP; Department of Infectious Diseases, Medicine School, Positive University, Curitiba, Paraná, Brazil., Koaski JC; Department of Infectious Diseases, Medicine School, Positive University, Curitiba, Paraná, Brazil., Albuquerque AS; Department of Infectious Diseases, Hospital Infection Control and Epidemiology Center, Santa Casa de Curitiba, Curitiba, Paraná, Brazil., Fachi MM; Value Management Office, Hospital Pequeno Príncipe, Curitiba, Paraná, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of global infectious diseases [J Glob Infect Dis] 2023 Aug 11; Vol. 15 (3), pp. 95-100. Date of Electronic Publication: 2023 Aug 11 (Print Publication: 2023). |
| DOI: | 10.4103/jgid.jgid_34_23 |
| Abstrakt: | Introduction: Multidrug-resistant bacterial infections limit available therapeutic options. Doxycycline is an old antibiotic from the tetracycline class that exhibits a wide antibacterial action, including Gram-negative bacteria (GNB), and could be an alternative for the treatment of multidrug-resistant (MDR) Enterobacteriaceae . The study aimed to systematically identify, evaluate, and summarize the results of studies related to outcomes of treatments for MDR-GNB infections in patients treated with doxycycline. Methods: This review was conducted in four databases during weeks 41-52 of 2022: PubMed, Medline, Scopus, and Web of Science, from the earliest year available on each database to December 2022. Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines were followed in conducting this study, and PICO was used for the research question of this review. Results: This scoping review found 8 retrospective studies that included 59 patients. Of these, 69% were treated for ventilator-associated pneumonia (VAP), 27% for urinary tract infections, 2% for bloodstream infections, and 2% for wound infections, both of which were associated with VAP. The usual dosage of doxycycline was 100 mg intravenously or orally. Clinical and microbiologic improvements were achieved in 81.3% and 87% of all patients, respectively. The mortality rate was 17.3% and was exclusively due to VAP. Conclusions: Doxycycline showed promising results in this review; however, randomized clinical trials or prospective cohorts are recommended to demonstrate the efficacy of doxycycline in the treatment of MDR infections with GNB. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Journal of Global Infectious Diseases.) |
| Databáze: | MEDLINE |
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