Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection.

Autor:	He X; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China xiawei5@mail.sysu.edu.cn.; School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University Wenzhou Zhejiang 325035 China., Han B; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China xiawei5@mail.sysu.edu.cn., Wang R; Department of Chemistry, The University of Hong Kong Pokfulam Road Hong Kong P. R. China hsun@hku.hk.; Department of Microbiology and State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong Hong Kong P. R. China., Guo Y; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China xiawei5@mail.sysu.edu.cn., Kao RYT; Department of Microbiology and State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong Hong Kong P. R. China., Li H; Department of Chemistry, The University of Hong Kong Pokfulam Road Hong Kong P. R. China hsun@hku.hk., Sun H; Department of Chemistry, The University of Hong Kong Pokfulam Road Hong Kong P. R. China hsun@hku.hk., Xia W; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China xiawei5@mail.sysu.edu.cn.
Jazyk:	angličtina
Zdroj:	RSC chemical biology [RSC Chem Biol] 2023 Aug 11; Vol. 4 (10), pp. 774-784. Date of Electronic Publication: 2023 Aug 11 (Print Publication: 2023).
DOI:	10.1039/d3cb00033h
Abstrakt:	The opportunistic pathogen Pseudomonas aeruginosa ( P. aeruginosa ) causes infections that are difficult to treat, which is due to the bacterial natural resistance to antibiotics. The bacterium is also able to form a biofilm that protects the bacterium from clearance by the human immune system and leads to chronic infection. Herein, we synthesized and characterized a novel gallium compound that interferes with both the iron metabolism and quorum sensing system of P. aeruginosa to achieve a significant bactericidal activity. The compound could substantially reduce the secretion of bacterial virulence factors as well as eliminate biofilm formation. Integrative omics analysis indicates that this compound can significantly disturb the gene transcription and metabolism of P. aeruginosa . The effectiveness of the gallium compound was further validated in mammalian cell and murine skin infection models. Our study offers a new strategy to design new gallium-based antimicrobials to combat P. aeruginosa infection. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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