The Correlation of the Neutrophil-to-Lymphocyte Ratio With Microvascular Complications in Patients With Diabetes Mellitus.

Autor:	Mahajan M; Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Prasad MK; Internal Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Ashok C; Pathology, Rajendra Institute of Medical Sciences, Ranchi, IND., Guria RT; Internal Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Marandi S; Internal Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Vidyapati; Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Subrat S; Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Chowdhury A; Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Sep 03; Vol. 15 (9), pp. e44601. Date of Electronic Publication: 2023 Sep 03 (Print Publication: 2023).
DOI:	10.7759/cureus.44601
Abstrakt:	Background High neutrophil-to-lymphocyte ratio (NLR) may be used as a reliable measure of vascular complications and an indicator of poor outcomes in cases of diabetes mellitus (DM). Methods A prospective analytical cross-sectional observational study was conducted at the Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India. A total of 100 patients with DM who met the inclusion and exclusion criteria were included in the study. A pre-tested and semi-structured questionnaire was given to the patients. IBM SPSS software version 26 (IBM Corp., Armonk, NY, USA) and MedCalc trial version 20.114 (MedCalc Software Ltd., Ostend, Belgium) were used for data analysis. Logistic regression analysis was performed to determine the association of the NLR with microvascular complications. Results In our study, the male-to-female ratio was 1.78:1 (male: 64 (n)%, female: 36 (n)%). The mean age of our study population was 56.28 ± 13.24 years. Of 58 patients with microvascular complications, 34 had a high NLR, and 24 patients had a normal NLR. Of 42 patients without microvascular complications, only 14 had a high NLR, and the remaining 28 patients had a normal NLR (p = 0.012). Logistic regression was performed to analyze the association between the NLR and microvascular complications, which demonstrated a significant association (odds ratio (OR): 2.833, 95% confidence interval (CI): 1.238-6.481; p = 0.013). Conclusions Our study demonstrated the higher odds of having microvascular complications among diabetics with a high NLR compared with non-diabetics. Therefore, the NLR may be used as a measure of microvascular complications in the diabetic population. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Mahajan et al.)
Databáze:	MEDLINE
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