| Autor: |
Tcheuko AS; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Hodjie BSF; Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon., Tadjong Tcho A; Department of Chemistry, University of Buea, Faculty of Sciences, Buea, Cameroon., Mohammed FN; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Ehawa Essoung FR; University Institute of Technology, University of Ngaoundere, Ngaoundere, Cameroon., Isyaka MS; Department of Chemical Sciences, Faculty of Science, Pen Resource University, Gombe, Nigeria.; Department of Chemical Sciences, Faculty of Science, Federal University of Kashere, Gombe, Nigeria., Mas-Claret E; Royal Botanic Gardens Kew, Richmond, UK., Langat MK; Department of Chemical Sciences, Faculty of Science, Pen Resource University, Gombe, Nigeria.; Royal Botanic Gardens Kew, Richmond, UK., Wansi JD; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Kamdem AFW; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon. |
| Abstrakt: |
The chemical investigation of the methanol extract of the roots of Caloncoba lophocarpa (Oliv.) Gilg. exhibited a new 30-norfriedelane triterpenoid, laphocarpanol ( 1 ), together with seven known compounds, caloncobalactone ( 2 ), friedelin ( 3 ), friedelanol (4 ), asperphernamate ( 5 ), stigmasterol ( 6 ), sitosterol ( 7 ) and sitosterol-3- O - β -D-glucopyranoside ( 8 ). The structures of the compounds were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antifungal and antibacterial activities. Compound 1 displayed weak antibacterial effect with MIC value of 62.5 μg/mL against Shigella flexineri . All the isolates were found to be inactive against the tested fungal strains. |
