Evolution and divergence of the genetic lineage Desmodus rotundus/Artibeus lituratus of rabies virus in São Paulo State.

Autor: de Souza DN; Pasteur Institute, São Paulo, SP, Brazil. deborardns.unesp@gmail.com., Oliveira RN; Pasteur Institute, São Paulo, SP, Brazil., Asprino PF; Centro de Oncologia Molecular, Hospital Sírio-Libanês, São Paulo, SP, Brazil., Bettoni F; Centro de Oncologia Molecular, Hospital Sírio-Libanês, São Paulo, SP, Brazil., Macedo CI; Pasteur Institute, São Paulo, SP, Brazil., Achkar SM; Pasteur Institute, São Paulo, SP, Brazil., Fahl WO; Pasteur Institute, São Paulo, SP, Brazil., Brandão PE; Departments of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil., Castilho JG; Pasteur Institute, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Archives of virology [Arch Virol] 2023 Oct 06; Vol. 168 (11), pp. 266. Date of Electronic Publication: 2023 Oct 06.
DOI: 10.1007/s00705-023-05864-w
Abstrakt: The last record of a rabies case caused by the dog-specific rabies virus (RABV) lineage in dogs or cats in São Paulo State was in 1998. From 2002 to 2021, 57 cases of rabies in these animals were reported, and the vast majority (51) were genetically characterized as belonging to the Desmodus rotundus/Artibeus lituratus RABV lineage. However, it is not currently possible to infer which of these bats is the source of infection by genome sequencing of RABV isolates. The aims of this study were (a) to characterize the Desmodus rotundus/Artibeus lituratus lineage to determine the relationships between the RABV lineages and each reservoir, (b) to assess the phylogeny and common ancestors of the RABV lineages found in D. rotundus and A. lituratus, and (c) to further understand the epidemiology and control of rabies. In this study, we genetically analyzed 70 RABV isolates from São Paulo State that were received by the Virology Laboratory of the Pasteur Institute of São Paulo between 2006 and 2015. Of these isolates, 33 were associated with the hematophagous bat D. rotundus and 37 with the fruit bat A. lituratus. A genomic approach using phylogenetic analysis and nucleotide sequence comparisons demonstrated that these isolates belonged to the same genetic lineage of RABV. We also found that, in São Paulo State, the D. rotundus/A. lituratus lineage could be subdivided into at least four phylogenetic sublineages: two associated with D. rotundus and two with A. lituratus. These results are of importance for the epidemiological surveillance of rabies in São Paulo.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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