Quantitative ultrasonographic examination of cerebral white matter by pixel brightness intensity as marker of middle-term neurodevelopment: a prospective observational study.

Autor: Laccetta G; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy. gianluigi.laccetta@uniroma1.it., Di Chiara M; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., De Nardo MC; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., Tagliabracci M; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., Travaglia E; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., De Santis B; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., Spiriti C; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., Dito L; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., Regoli D; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., Caravale B; Department of Developmental and Social Psychology, Sapienza University of Rome, Rome, Italy., Cellitti R; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy., Parisi P; Department of Neuroscience, Mental Health and Sense Organs (NESMOS), Faculty of Medicine and Psychology, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy., Terrin G; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Oct 05; Vol. 13 (1), pp. 16816. Date of Electronic Publication: 2023 Oct 05.
DOI: 10.1038/s41598-023-44083-w
Abstrakt: Non-cystic white matter (WM) injury has become prevalent among preterm newborns and is associated with long-term neurodevelopmental impairment. Magnetic resonance is the gold-standard for diagnosis; however, cranial ultrasound (CUS) is more easily available but limited by subjective interpretation of images. To overcome this problem, we enrolled in a prospective observational study, patients with gestational age at birth < 32 weeks with normal CUS scans or grade 1 WM injury. Patients underwent CUS examinations at 0-7 days of life (T 0 ), 14-35 days of life (T 1 ), 37 0/7 -41 6/7  weeks' postmenstrual age (T 2 ), and 42 0/7 -52 0/7  weeks' postmenstrual age (T 3 ). The echogenicity of parieto-occipital periventricular WM relative to that of homolateral choroid plexus (RE CP ) was calculated on parasagittal scans by means of pixel brightness intensity and its relationship with Bayley-III assessment at 12 months' corrected age was evaluated. We demonstrated that: (1) Left RE CP values at T 1 negatively correlated with cognitive composite scores; (2) Right RE CP values at T 2 and T 3 negatively correlated with language composite scores; (3) Left RE CP values at T 1 and T 2 negatively correlated with motor composite scores. Thus, this technique may be used as screening method to early identify patients at risk of neurodevelopmental issues and promptly initiate preventive and therapeutic interventions.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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