Hippocampal neurons code individual episodic memories in humans.

Autor: Kolibius LD; Department of Biomedical Engineering, Columbia University, New York, NY, USA. luca.kolibius@columbia.edu.; Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK. luca.kolibius@columbia.edu.; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK. luca.kolibius@columbia.edu., Roux F; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK., Parish G; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK., Ter Wal M; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK., Van Der Plas M; Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK.; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK., Chelvarajah R; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK.; Complex Epilepsy and Surgery Service, Neurosciences Centre, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Sawlani V; Complex Epilepsy and Surgery Service, Neurosciences Centre, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Rollings DT; Complex Epilepsy and Surgery Service, Neurosciences Centre, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Lang JD; Epilepsy Center, Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Gollwitzer S; Epilepsy Center, Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Walther K; Epilepsy Center, Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Hopfengärtner R; Epilepsy Center, Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Kreiselmeyer G; Epilepsy Center, Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Hamer H; Epilepsy Center, Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Staresina BP; Department of Experimental Psychology, University of Oxford, Oxford, UK.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK., Wimber M; Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK.; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK., Bowman H; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK.; Centre for Cognitive Neuroscience and Cognitive Systems and the School of Computing, University of Kent, Canterbury, UK., Hanslmayr S; Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK. simon.hanslmayr@glasgow.ac.uk.; Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK. simon.hanslmayr@glasgow.ac.uk.
Jazyk: angličtina
Zdroj: Nature human behaviour [Nat Hum Behav] 2023 Nov; Vol. 7 (11), pp. 1968-1979. Date of Electronic Publication: 2023 Oct 05.
DOI: 10.1038/s41562-023-01706-6
Abstrakt: The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. Here we provide evidence for the latter hypothesis. Using single-neuron recordings from a total of 30 participants, we show that individual neurons, which we term episode-specific neurons, code discrete episodic memories using either a rate code or a temporal firing code. These neurons were observed exclusively in the hippocampus. Importantly, these episode-specific neurons do not reflect the coding of a particular element in the episode (that is, concept or time). Instead, they code for the conjunction of the different elements that make up the episode.
(© 2023. The Author(s).)
Databáze: MEDLINE
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