TEAM Study: Upfront Docetaxel Treatment in Patients With Metastatic Hormone-Sensitive Prostate Cancer: A Real-World, Multicenter, Retrospective Analysis.

Autor: Pisano C; Department of Medical Oncology, S Croce e Carle Hospital, Cuneo, Italy., Turco F; Department of Oncology, San Luigi Gonzaga University Hospital, University of Turin, Orbassano, Italy., Arnaudo E; Department of Oncology, San Luigi Gonzaga University Hospital, University of Turin, Orbassano, Italy., Fea E; Department of Medical Oncology, S Croce e Carle Hospital, Cuneo, Italy., Vanella P; Department of Medical Oncology, S Croce e Carle Hospital, Cuneo, Italy., Ruatta F; Department of Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Filippi R; Department of Oncology, San Luigi Gonzaga University Hospital, University of Turin, Orbassano, Italy; Division of Medical Oncology 1, Department of Oncology, Città della Salute e della Scienza Hospital, Turin, Italy., Brusa F; Department of Medical Oncology, Cardinal Massaia Hospital, Asti, Italy., Prati V; Department of Medical Oncology, Michele e Pietro Ferrero Hospital, Verduno-Azienda Sanitaria Locale CN2, Alba-Bra, Cuneo, Italy., Vana F; Department of Oncology, San Giovanni Bosco Hospital, Turin, Italy., Mennitto A; Medical Oncology-Department of Translational Medicine (DIMET), Università del Piemonte Orientale (UPO), Maggiore della Carità University Hospital, Novara, Italy., Cattrini C; Medical Oncology-Department of Translational Medicine (DIMET), Università del Piemonte Orientale (UPO), Maggiore della Carità University Hospital, Novara, Italy., Vignani F; Department of Oncology, Ordine Mauriziano Hospital, University of Turin, Turin, Italy., Dionisio R; Department of Oncology, Ordine Mauriziano Hospital, University of Turin, Turin, Italy., Icardi M; Division of Medical Oncology 2, Department of Oncology, Città della Salute e della Scienza Hospital, Turin, Italy., Guglielmini P; Oncology Unit, S. Spirito Hospital, Casale Monferrato, Alessandria, Italy., Buosi R; Oncology Unit, S. Spirito Hospital, Casale Monferrato, Alessandria, Italy., Stevani I; Oncology Unit, S. Spirito Hospital, Casale Monferrato, Alessandria, Italy., Vormola R; Department of Oncology, Ivrea Community Hospital, Ivrea, Italy., Numico G; Department of Medical Oncology, S Croce e Carle Hospital, Cuneo, Italy., Depetris I; Division of Medical Oncology 1, Department of Oncology, Città della Salute e della Scienza Hospital, Turin, Italy., Comandone A; Department of Oncology, San Giovanni Bosco Hospital, Turin, Italy., Gennari A; Medical Oncology-Department of Translational Medicine (DIMET), Università del Piemonte Orientale (UPO), Maggiore della Carità University Hospital, Novara, Italy., Airoldi M; Division of Medical Oncology 2, Department of Oncology, Città della Salute e della Scienza Hospital, Turin, Italy., Rossi M; Oncology Unit, S. Spirito Hospital, Casale Monferrato, Alessandria, Italy., Vellani G; Department of Oncology, Ivrea Community Hospital, Ivrea, Italy., Ortega C; Department of Medical Oncology, Michele e Pietro Ferrero Hospital, Verduno-Azienda Sanitaria Locale CN2, Alba-Bra, Cuneo, Italy., Tucci M; Department of Medical Oncology, Cardinal Massaia Hospital, Asti, Italy. Electronic address: marcello.tucci@gmail.com., Maio MD; Department of Oncology, Ordine Mauriziano Hospital, University of Turin, Turin, Italy., Buttigliero C; Department of Oncology, San Luigi Gonzaga University Hospital, University of Turin, Orbassano, Italy.
Jazyk: angličtina
Zdroj: Clinical genitourinary cancer [Clin Genitourin Cancer] 2024 Apr; Vol. 22 (2), pp. 56-67.e16. Date of Electronic Publication: 2023 Sep 07.
DOI: 10.1016/j.clgc.2023.08.006
Abstrakt: Background: Treatment of metastatic hormone-sensitive prostate cancer (mHSPC) dramatically changed. PEACE-1 and ARASENS trials established triplet therapy efficacy. Identifying prognostic factors supporting treatment choice is pivotal.
Methods: TEAM is an observational, retrospective study to evaluate prognostic role of variables in mHSPC patients receiving upfront docetaxel in 11 Italian centers. Outcome measures were progression-free survival (PFS) and overall-survival (OS).
Results: From September 2014 to December 2020, 147 patients were included. Median PFS and OS were 11.6 and 37.4 months. At univariate analysis, PFS-related variables were Gleason Score (GS) (P = .001), opioid use (P = .004), bone metastases number (P < .001), baseline PSA (P = .006), Hb (P < .001), ALP (P < .001) and LDH (P = .002), time between ADT and docetaxel start (P = .018), 3-month PSA (P < .001) and ALP (P < .001), and number of docetaxel cycles (P < .001). OS-related variables were PSA at diagnosis (P = .024), primary tumor treatment (P = .022), baseline pain (P = .015), opioid use (P < .001), bone metastases number (P < . 001), baseline Hb (P < .001), ALP (P < .001) and LDH (P = .001), NLR ratio (P = .039), 3-month PSA (P < .001) and ALP (P < .001) and docetaxel cycles number (P < .001). At multivariate analysis, independent prognostic variables were GS, opioid use, baseline LDH and time between ADT and docetaxel initiation for PFS, and baseline Hb and LDH for OS.
Conclusion: Patients receiving upfront docetaxel with high GS, high disease burden, pain or opioid use, baseline unfavorable laboratory values had worse outcomes. Patients had greater docetaxel benefit when initiated early after ADT start. These parameters could be taken into account when selecting candidates for triplet therapy.
Competing Interests: Disclosure All authors have no conflict of interest to declare.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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