Novel aspects of taxifolin pharmacokinetics: Dose proportionality, cumulative effect, metabolism, microemulsion dosage forms.
Autor: | Lakeev AP; Scientific and Educational Center 'Perspective Materials and Technologies in Subsoil Use', Faculty of Chemistry, National Research Tomsk State University, 36, Lenin Ave., Tomsk 634050, Russia; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 3, Lenin Ave., Tomsk 634028, Russia. Electronic address: lakeevs@mail.ru., Yanovskaya EA; Scientific and Educational Center 'Perspective Materials and Technologies in Subsoil Use', Faculty of Chemistry, National Research Tomsk State University, 36, Lenin Ave., Tomsk 634050, Russia; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 3, Lenin Ave., Tomsk 634028, Russia. Electronic address: elena.yanovskaya@pharmso.ru., Yanovsky VA; Scientific and Educational Center 'Perspective Materials and Technologies in Subsoil Use', Faculty of Chemistry, National Research Tomsk State University, 36, Lenin Ave., Tomsk 634050, Russia., Frelikh GA; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 3, Lenin Ave., Tomsk 634028, Russia., Andropov MO; Scientific and Educational Center 'Perspective Materials and Technologies in Subsoil Use', Faculty of Chemistry, National Research Tomsk State University, 36, Lenin Ave., Tomsk 634050, Russia. |
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Jazyk: | angličtina |
Zdroj: | Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2023 Nov 30; Vol. 236, pp. 115744. Date of Electronic Publication: 2023 Sep 22. |
DOI: | 10.1016/j.jpba.2023.115744 |
Abstrakt: | Taxifolin (TFL) is a small drug molecule with a broad therapeutic potential limited by its poor aqueous solubility and excessive metabolism. Despite comprehensive research, some aspects of the TFL pharmacokinetics, e.g., dose proportionality and possible cumulative effect, remain unexplored. In the current study, we have tried to fill this gap. Our results revealed that the TFL pharmacokinetics in rats had nonlinear character in the dose range of 10-50 mg/kg after its single oral administration (AUC). For C Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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