Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.

Autor: Djerdjaj A; Department of Psychology & Neuroscience, Boston College, Chestnut Hill, MA, United States of America., Rieger NS; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States of America., Brady BH; Department of Psychology & Neuroscience, Boston College, Chestnut Hill, MA, United States of America., Carey BN; Department of Psychology & Neuroscience, Boston College, Chestnut Hill, MA, United States of America., Ng AJ; Department of Psychology & Neuroscience, Boston College, Chestnut Hill, MA, United States of America., Christianson JP; Department of Psychology & Neuroscience, Boston College, Chestnut Hill, MA, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Oct 05; Vol. 18 (10), pp. e0281794. Date of Electronic Publication: 2023 Oct 05 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0281794
Abstrakt: The ability to detect, appraise, and respond to another's emotional state is essential to social affective behavior. This is mediated by a network of brain regions responsible for integrating external cues with internal states to orchestrate situationally appropriate behavioral responses. The basolateral amygdala (BLA) and the insular cortex are reciprocally connected regions involved in social cognition and prior work in male rats revealed their contributions to social affective behavior. We investigated the functional role of these regions in female rats in a social affective preference (SAP) test in which experimental rats approach stressed juvenile but avoid stressed adult conspecifics. In separate experiments, the BLA or the insula were inhibited by local infusion of muscimol (100ng/side in 0.5μL saline) or vehicle prior to SAP tests. In both regions, muscimol interfered with preference for the stressed juvenile and naive adult, indicating that these regions are necessary for appropriate social affective behavior. In male rats, SAP behavior requires insular oxytocin but there are noteworthy sex differences in the oxytocin receptor distribution in rats. Oxytocin (500nM) administered to the insula did not alter social behavior but oxytocin infusions to the BLA increased social interaction. In sum, female rats appear to use the same BLA and insula regions for social affective behavior but sex differences exist in contribution of oxytocin in the insula.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Djerdjaj et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje