Assessing the associations between known genetic variants and substance use in people with HIV in the United States.

Autor: Haas CB; Department of Epidemiology, University of Washington, Seattle, WA, United States of America., Jordahl KM; Department of Epidemiology, University of Washington, Seattle, WA, United States of America., Nance RM; Department of Medicine, University of Washington, Seattle, WA, United States of America., Whitney BM; Department of Medicine, University of Washington, Seattle, WA, United States of America., Wang L; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States of America., Delaney JAC; University of Manitoba, Max Rady College of Medicine, Manitoba, Canada., Ruderman S; Department of Epidemiology, University of Washington, Seattle, WA, United States of America., Jia T; Department of Epidemiology, University of Washington, Seattle, WA, United States of America., Mathews WC; Department of Medicine, University of California at San Diego, San Diego, CA, United States of America., Saag MS; Department of Medicine at the School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Lee SA; Department of Medicine, University of California at San Francisco, San Francisco, CA, United States of America., Napravnik S; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America., Jacobson JM; Center for AIDS Research, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, OH, United States of America., Chander G; Department of Medicine, University of Washington, Seattle, WA, United States of America.; Department of Medicine, Johns Hopkins University, Baltimore, MD, United States of America., McCall EM; Department of Medicine, Johns Hopkins University, Baltimore, MD, United States of America., Moore RD; Department of Medicine, Johns Hopkins University, Baltimore, MD, United States of America., Mayer KH; Harvard Medical School, Beth Israel Deaconess Medical Center, Fenway Health, Boston, MA, United States of America., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, United States of America., Lee WJ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Crane PK; Department of Medicine, University of Washington, Seattle, WA, United States of America., Crane H; Department of Medicine, University of Washington, Seattle, WA, United States of America., Peter I; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America., Lindström S; Department of Epidemiology, University of Washington, Seattle, WA, United States of America.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Oct 05; Vol. 18 (10), pp. e0292068. Date of Electronic Publication: 2023 Oct 05 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0292068
Abstrakt: Background: The prevalence of substance use in people with HIV (PWH) in the United States is higher than in the general population and is an important driver of HIV-related outcomes. We sought to assess if previously identified genetic associations that contribute to substance use are also observed in a population of PWH.
Methods: We performed genome-wide association studies (GWAS) of alcohol, smoking, and cannabis use phenotypes in a multi-ancestry population of 7,542 PWH from the Center for AIDS Research Network of Integrated Clinical Systems (CNICS). We conducted multi-ancestry GWAS for individuals of African (n = 3,748), Admixed American (n = 1,334), and European (n = 2,460) ancestry. Phenotype data were self-reported and collected using patient reported outcomes (PROs) and three questions from AUDIT-C, an alcohol screening tool. We analyzed nine phenotypes: 1) frequency of alcohol consumption, 2) typical number of drinks on a day when drinking alcohol, 3) frequency of five or more alcoholic drinks in a 30-day period, 4) smoking initiation, 5) smoking cessation, 6) cigarettes per day, 7) cannabis use initiation, 8) cannabis use cessation, 9) frequency of cannabis use during the previous 30 days. For each phenotype we considered a) variants previously identified as associated with a substance use trait and b) novel associations.
Results: We observed evidence for effects of previously reported single nucleotide polymorphisms (SNPs) related to alcohol (rs1229984, p = 0.001), tobacco (rs11783093, p = 2.22E-4), and cannabis use (rs2875907, p = 0.005). We also report two novel loci (19p13.2, p = 1.3E-8; and 20p11.21, p = 2.1E-8) associated with cannabis use cessation.
Conclusions: Our analyses contribute to understanding the genetic bases of substance use in a population with relatively higher rates of use compared to the general population.
Competing Interests: KMJ was employed by Bristol-Myers Squibb during the drafting of this manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials. All other authors report no conflicts of interest to disclose.
(Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.)
Databáze: MEDLINE
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