An adenosine derivative prevents the alterations observed in metabolic syndrome in a rat model induced by a rich high-fat diet and sucrose supplementation.

Autor: Chávez E; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico., Aparicio-Cadena AR; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico., Velasco-Loyden G; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico., Lozano-Rosas MG; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico., Domínguez-López M; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico., Cancino-Bello A; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico., Torres N; Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán', Mexico City, Mexico., Tovar AR; Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán', Mexico City, Mexico., Cabrera-Aguilar A; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico., Chagoya-de Sánchez V; Instituto de Fisiología Celular, Departamento de Biología Celular y del Desarrollo, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Oct 05; Vol. 18 (10), pp. e0292448. Date of Electronic Publication: 2023 Oct 05 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0292448
Abstrakt: Metabolic syndrome is a multifactorial disease with high prevalence worldwide. It is related to cardiovascular disease, diabetes, and obesity. Approximately 80% of patients with metabolic syndrome have some degree of fatty liver disease. An adenosine derivative (IFC-305) has been shown to exert protective effects in models of liver damage as well as on elements involved in central metabolism; therefore, here, we evaluated the effect of IFC-305 in an experimental model of metabolic syndrome in rats induced by a high-fat diet and 10% sucrose in drinking water for 18 weeks. We also determined changes in fatty acid uptake in the Huh-7 cell line. In the experimental model, increases in body mass, serum triglycerides and proinflammatory cytokines were induced in rats, and the adenosine derivative significantly prevented these changes. Interestingly, IFC-305 prevented alterations in glucose and insulin tolerance, enabling the regulation of glucose levels in the same way as in the control group. Histologically, the alterations, including mitochondrial morphological changes, observed in response to the high-fat diet were prevented by administration of the adenosine derivative. This compound exerted protective effects against metabolic syndrome, likely due to its action in metabolic regulation, such as in the regulation of glucose blood levels and hepatocyte fatty acid uptake.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Chávez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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