Frequency and burden of disease for SARS-CoV-2 and other viral respiratory tract infections in children under the age of 2 months.

Autor: Latouche M; Pediatric Emergency Unit and Infectious Diseases, Univ. Lille, CHU Lille, Lille, France., Ouafi M; Laboratoire de Virologie ULR3610, Univ. Lille, CHU Lille, Lille, France., Engelmann I; Laboratoire de Virologie ULR3610, Univ. Lille, CHU Lille, Lille, France., Becquart A; Laboratoire de Virologie ULR3610, Univ. Lille, CHU Lille, Lille, France., Alidjinou EK; Laboratoire de Virologie ULR3610, Univ. Lille, CHU Lille, Lille, France., Mitha A; CHU Lille, Pediatric and Neonatal Intensive Care Transport Unit, Department of Emergency Medicine, SAMU 59, Lille, France.; Université de Paris, Epidemiology and Statistics Research Center/CRESS, INSERM (U1153 - Obstetrical, perinatal and Pediatric Epidemiology Research Team (EPOPé)), INRA, Hôpital Tenon, Bâtiment Recherche, Paris, France., Dubos F; Pediatric Emergency Unit and Infectious Diseases, Univ. Lille, CHU Lille, Lille, France.; Évaluation des Technologies de Santé et des Pratiques Médicales, Univ. Lille, ULR2694 METRICS, Lille, France.
Jazyk: angličtina
Zdroj: Pediatric pulmonology [Pediatr Pulmonol] 2024 Jan; Vol. 59 (1), pp. 101-110. Date of Electronic Publication: 2023 Oct 05.
DOI: 10.1002/ppul.26718
Abstrakt: Objective: To evaluate the frequency and burden of disease of SARS-CoV-2 and other respiratory viruses in children under the age of 2 months.
Methods: A retrospective, cross-sectional, single-center study was conducted between March 2021 and February 2022. All children under the age of 2 months and tested for SARS-CoV-2 were included. The frequency of SARS-CoV-2, of other respiratory viruses and the burden of disease caused by SARS-CoV-2 and other respiratory viruses were evaluated.
Results: Seven hundred and twenty-seven children with an RT-PCR test for SARS-CoV-2 were included (mean age: 0.9 months (±0.6); boys: 57%); 514 (71%) in the emergency room and 213 (29%) in hospital. Among them, 62 (8.5%) had a positive RT-PCR test for SARS-CoV-2, more often in the Omicron period (23%) than in the Alpha period (4%). Of the 565 (78%) with a multiplex RT-PCR test for other viruses, 325 (58%) were positive. Children with a positive SARS-CoV-2 were less likely to have required respiratory support (p = 0.001), enteral nutrition (p = 0.03), or intensive care admission (p = 0.01) and had a shorter hospital stay than children with other respiratory viruses (5 days vs. 7 days, p = 0.007).
Conclusion: In this young population of children, SARS-CoV-2 infection was less frequent and less severe than other viral respiratory infections.
(© 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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