Effects of Omalizumab on Serum Levels of Substance P, Calcitonin Gene-Related Peptide, Neuropeptide Y, and Interleukin-31 in Patients with Chronic Spontaneous Urticaria.

Autor: Boyvadoglu C; Department of Dermatology, Ceyhan State Hospital, Adana, Turkey., Ulusal H; Department of Medical Biochemistry, University of Gaziantep Faculty of Medicine, Gaziantep, Turkey., Taysı S; Department of Medical Biochemistry, University of Gaziantep Faculty of Medicine, Gaziantep, Turkey., Ozaydin-Yavuz G; Department of Dermatology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey., Yavuz IH; Department of Dermatology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey., Korkmaz P; Department of Dermatology, Ersin Arslan Training and Research Hospital, Gaziantep, Turkey., Inaloz HS; Department of Dermatology, University of Gaziantep Faculty of Medicine, Gaziantep, Turkey.
Jazyk: angličtina
Zdroj: Mediators of inflammation [Mediators Inflamm] 2023 Sep 26; Vol. 2023, pp. 8087274. Date of Electronic Publication: 2023 Sep 26 (Print Publication: 2023).
DOI: 10.1155/2023/8087274
Abstrakt: The mechanism of action of omalizumab in urticaria is still not literally known. This study examines the serum values of substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), and interleukin-31 (IL-31) in patients using omalizumab. In this study, 30 patients with chronic spontaneous urticaria (CSU) who were going to be treated with omalizumab and 20 healthy volunteers took part. Demographic data, clinical data, and disease activity scores were noted. For serum SP, CGRP, NPY, and IL-31 values, 10 mL of blood were taken from the patients before starting the treatment, 3 months after the treatment, at the end of the 6th month, and from healthy volunteers all at once. The change in values measured at baseline, 3rd month, and 6th month was analyzed by the Friedman Test. The Mann-Whitney U test was used to compare the parameters obtained from the patients and control groups. The significance level was set at p =0.05. SP, CGRP, NPY, and IL-31 values were all statistically significantly lower in the CSU patient group compared to the control group. After treatment, the levels of SP and CGRP in the serum went up, and the levels of serum IL-31 went down. These changes were statistically significant. This study supports the view that omalizumab does not only affect IgE receptors but also affects mast cells through other mechanisms. According to our knowledge, this is the first study to show that omalizumab therapy and serum CGRP levels are related.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Cagdas Boyvadoglu et al.)
Databáze: MEDLINE
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