C is -9, trans -11 and trans -10, cis -12 conjugated linoleic acid gastric administration during the pregestational and gestational periods does not influence the follicular endowment of the progeny.

Autor:	de Freitas DS; Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei, São João del-Rei, MG, Brasil., Lopes GAG; Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei, São João del-Rei, MG, Brasil., Nascimento BR; Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei, São João del-Rei, MG, Brasil., Madureira AP; Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei, São João del-Rei, MG, Brasil., Campos-Junior PHA; Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei, São João del-Rei, MG, Brasil.
Jazyk:	angličtina
Zdroj:	Animal reproduction [Anim Reprod] 2023 Sep 18; Vol. 20 (3), pp. e20220124. Date of Electronic Publication: 2023 Sep 18 (Print Publication: 2023).
DOI:	10.1590/1984-3143-AR2022-0124
Abstrakt:	Fetal programming suggests that maternal stimulation and nutrition during the period of fetal development can program the progeny. Conjugated linoleic acid (CLA), an isomer of linoleic acid, has been characterized in several aspects, but few studies have been performed on its involvement in reproduction and fetal programming. The aim of this study was to evaluate the F1, F2 and F3 progeny of female mice supplemented with CLA during the pregestational and gestational periods with respect to biometric and reproductive parameters, as well as ovarian morphophysiology. The F1 progeny of mothers supplemented with CLA exhibited stable weight gain, while the F2 progeny showed no effects (P=0.0187 and P=0.0245, respectively). A reduction in Lee's Index was observed in both generations at the second post-weaning evaluation week in the animals treated with CLA (P=0.0100 and P=0.0078, respectively). The F2 generation showed an increase in the anogenital index in both sexes of the animals treated with CLA (P= 0.0114 and P<0.0001, female and male respectively). CLA administration to mothers did not affect any of the following in their progeny: ovarian follicle mobilization (P>0.05), follicle number (P>0.05) and the integrated density of the lipid content of oocytes included in antral follicles (P>0.05). This study evaluated the use of CLA in mothers and found that it did not affect the progeny regarding murine reproductive performance, suggesting that this supplement can be used safely. Competing Interests: Conflict of Interest: The authors declare that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.
Databáze:	MEDLINE
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