The effect of a multicomponent oral care regimen on gingival inflammation: A randomized controlled clinical trial.

Autor: do Amaral GCLS; Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil., Hassan MA; Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil., Saraiva L; Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil., Nakao LYS; Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil., Holzhausen M; Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil., Malheiros ZM; Colgate-Palmolive, Piscataway, New Jersey, USA., Stewart B; Colgate-Palmolive, Piscataway, New Jersey, USA., Romito GA; Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil., Villar CC; Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of periodontology [J Periodontol] 2024 Apr; Vol. 95 (4), pp. 350-359. Date of Electronic Publication: 2023 Oct 04.
DOI: 10.1002/JPER.23-0361
Abstrakt: Background: Oral care regimens can be explored to improve oral health in patients with gingivitis. This study aimed to evaluate the efficacy of a multicomponent oral care regimen with a dual zinc plus arginine (DZA) toothpaste and cetylpyridinium chloride with zinc lactate (CPC + Zn) mouthwash in reducing gingival bleeding in patients with gingivitis.
Methods: This randomized clinical trial included 94 participants with gingivitis who were randomized into two groups: the DZA/CPC + Zn group, which used a 1450-ppm fluoride toothpaste containing 0.96% zinc plus 1.5% arginine and a fluoride-containing mouthwash with 0.075% CPC and 0.28% zinc lactate, and the control group, which used a 1450-ppm fluoride toothpaste and a placebo mouthwash for 6 months. All participants were examined by a blinded examiner who measured the gingival index, plaque index, and gingival severity index. Data were analyzed using paired t test, independent t test, and analysis of covariance (ANCOVA).
Results: Both groups presented statistically significant reductions in all clinical parameters compared to baseline. The DZA/CPC + Zn group exhibited significantly greater reductions in gingival index, gingival severity index, proximal gingival index, plaque index and proximal plaque index compared to the control group at 1, 3, and 6 months. Furthermore, DZA/CPC + Zn significantly decreased the percentage of patients with generalized gingivitis over a 6-month follow-up period. However, differences between the DZA/CPC + Zn and the control groups were not maintained after both groups established similar regimens with fluoride toothpaste.
Conclusion: The multicomponent oral care regimen consisting of DZA toothpaste and CPC + Zn mouthwash is effective in reducing gingival inflammation and supragingival biofilm in patients with gingivitis.
(© 2023 American Academy of Periodontology.)
Databáze: MEDLINE
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