Pangolin Genomes Offer Key Insights and Resources for the World's Most Trafficked Wild Mammals.

Autor:	Heighton SP; Laboratoire Evolution et Diversité Biologique (EDB)- IRD-UPS-CNRS, Université Toulouse III, Toulouse, France., Allio R; Institut des Sciences de l'Évolution de Montpellier (ISEM), Université de Montpellier, CNRS, IRD, Montpellier, France., Murienne J; Laboratoire Evolution et Diversité Biologique (EDB)- IRD-UPS-CNRS, Université Toulouse III, Toulouse, France., Salmona J; Laboratoire Evolution et Diversité Biologique (EDB)- IRD-UPS-CNRS, Université Toulouse III, Toulouse, France., Meng H; The State Key Laboratory of Protein and Plant Gene Research of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China., Scornavacca C; Institut des Sciences de l'Évolution de Montpellier (ISEM), Université de Montpellier, CNRS, IRD, Montpellier, France., Bastos ADS; Mammal Research Institute, Department of Zoology & Entomology, University of Pretoria, Pretoria, South Africa., Njiokou F; Laboratoire de Parasitologie et Ecologie, Faculté des Sciences, Université de Yaoundé I, Yaoundé, Cameroon., Pietersen DW; Mammal Research Institute, Department of Zoology & Entomology, University of Pretoria, Pretoria, South Africa., Tilak MK; Institut des Sciences de l'Évolution de Montpellier (ISEM), Université de Montpellier, CNRS, IRD, Montpellier, France., Luo SJ; The State Key Laboratory of Protein and Plant Gene Research of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China., Delsuc F; Institut des Sciences de l'Évolution de Montpellier (ISEM), Université de Montpellier, CNRS, IRD, Montpellier, France., Gaubert P; Laboratoire Evolution et Diversité Biologique (EDB)- IRD-UPS-CNRS, Université Toulouse III, Toulouse, France.; CIIMAR/CIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade 16 do Porto, Terminal de Cruzeiros do Porto de Leixões, Porto, Portugal.
Jazyk:	angličtina
Zdroj:	Molecular biology and evolution [Mol Biol Evol] 2023 Oct 04; Vol. 40 (10).
DOI:	10.1093/molbev/msad190
Abstrakt:	Pangolins form a group of scaly mammals that are trafficked at record numbers for their meat and purported medicinal properties. Despite their conservation concern, knowledge of their evolution is limited by a paucity of genomic data. We aim to produce exhaustive genomic resources that include 3,238 orthologous genes and whole-genome polymorphisms to assess the evolution of all eight extant pangolin species. Robust orthologous gene-based phylogenies recovered the monophyly of the three genera and highlighted the existence of an undescribed species closely related to Southeast Asian pangolins. Signatures of middle Miocene admixture between an extinct, possibly European, lineage and the ancestor of Southeast Asian pangolins, provide new insights into the early evolutionary history of the group. Demographic trajectories and genome-wide heterozygosity estimates revealed contrasts between continental versus island populations and species lineages, suggesting that conservation planning should consider intraspecific patterns. With the expected loss of genomic diversity from recent, extensive trafficking not yet realized in pangolins, we recommend that populations be genetically surveyed to anticipate any deleterious impact of the illegal trade. Finally, we produce a complete set of genomic resources that will be integral for future conservation management and forensic endeavors for pangolins, including tracing their illegal trade. These comprise the completion of whole-genomes for pangolins through the hybrid assembly of the first reference genome for the giant pangolin (Smutsia gigantea) and new draft genomes (∼43x-77x) for four additional species, as well as a database of orthologous genes with over 3.4 million polymorphic sites. Competing Interests: Conflict of interest statement. The authors declare no competing/conflict of interests. (© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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