Investigating the determinants of iridolenticular contact area: a novel parameter for angle closure.

Autor:	Tun TA; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Nongpiur ME; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Xu BY; Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Wang X; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China., Tan M; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.; Ophthalmology Service, Jurong Health Service, Singapore., Quah JHM; SingHealth Polyclinics, Outram, Singapore., Lim HB; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore., Cheng CY; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Aung T; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore aung.tin@snec.com.sg.; Duke-NUS Medical School, Singapore.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2024 Jun 20; Vol. 108 (7), pp. 940-945. Date of Electronic Publication: 2024 Jun 20.
DOI:	10.1136/bjo-2022-322810
Abstrakt:	Background/aims: To identify ocular determinants of iridolenticular contact area (ILCA), a recently introduced swept-source optical coherence tomography (SSOCT) derived parameter, and assess the association between ILCA and angle closure. Methods: In this population-based cross-sectional study, right eyes of 464 subjects underwent SSOCT (SS-1000, CASIA, Tomey Corporation, Nagoya, Japan) imaging in the dark. Eight out of 128 cross-sectional images (evenly spaced 22.5° apart) were selected for analysis. Matlab (Matworks, Massachusetts, USA) was used to measure ILCA, defined as the circumferential extent of contact area between the pigmented iris epithelium and anterior lens surface. Gonioscopic angle closure (GAC) was defined as non-visibility of the posterior trabecular meshwork in two or more angle quadrants. Results: The mean age of subjects was 62±6.6 years, with the majority being female (65.5%). 143/464 subjects (28.6%) had GAC. In multivariable linear regression analysis, ILCA was significantly associated with anterior chamber width (β=1.03, p=0.003), pupillary diameter (β=-1.9, p<0.001) and iris curvature (β=-17.35, p<0.001). ILCA was smaller in eyes with GAC compared with those with open angles (4.28±1.6 mm 2 vs 6.02±2.71 mm 2 , p<0.001). ILCA was independently associated with GAC (β=-0.03, p<0.001), iridotrabecular contact index (β=-6.82, p<0.001) or angle opening distance (β=0.02, p<0.001) after adjusting for covariates. The diagnostic performance of ILCA for detecting GAC was acceptable (AUC=0.69). Conclusions: ILCA is a significant predictor of angle closure independent of other biometric factors and may reflect unique anatomical information associated with pupillary block. ILCA represents a novel biometric risk factor in eyes with angle closure. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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