Patterns of reproduction and autozygosity distinguish the breeding from nonbreeding gray wolves of Yellowstone National Park.

Autor:	vonHoldt BM; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States., DeCandia AL; Department of Biology, Georgetown University, Washington, DC, United States.; Center for Conservation Genomics, Smithsonian's National Zoo and Conservation Biology Institute, Washington, DC, United States., Cassidy KA; Yellowstone Center for Resources, Yellowstone National Park, WY, United States., Stahler EE; Yellowstone Center for Resources, Yellowstone National Park, WY, United States., Sinsheimer JS; Department of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, United States.; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.; Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States., Smith DW; Yellowstone Center for Resources, Yellowstone National Park, WY, United States., Stahler DR; Yellowstone Center for Resources, Yellowstone National Park, WY, United States.
Jazyk:	angličtina
Zdroj:	The Journal of heredity [J Hered] 2024 Jul 10; Vol. 115 (4), pp. 327-338.
DOI:	10.1093/jhered/esad062
Abstrakt:	For species of management concern, accurate estimates of inbreeding and associated consequences on reproduction are crucial for predicting their future viability. However, few studies have partitioned this aspect of genetic viability with respect to reproduction in a group-living social mammal. We investigated the contributions of foundation stock lineages, putative fitness consequences of inbreeding, and genetic diversity of the breeding versus nonreproductive segment of the Yellowstone National Park gray wolf population. Our dataset spans 25 years and seven generations since reintroduction, encompassing 152 nuclear families and 329 litters. We found more than 87% of the pedigree foundation genomes persisted and report influxes of allelic diversity from two translocated wolves from a divergent source in Montana. As expected for group-living species, mean kinship significantly increased over time but with minimal loss of observed heterozygosity. Strikingly, the reproductive portion of the population carried a significantly lower genome-wide inbreeding coefficients, autozygosity, and more rapid decay for linkage disequilibrium relative to the nonbreeding population. Breeding wolves had significantly longer lifespans and lower inbreeding coefficients than nonbreeding wolves. Our model revealed that the number of litters was negatively significantly associated with heterozygosity (R = -0.11). Our findings highlight genetic contributions to fitness, and the importance of the reproductively active individuals in a population to counteract loss of genetic variation in a wild, free-ranging social carnivore. It is crucial for managers to mitigate factors that significantly reduce effective population size and genetic connectivity, which supports the dispersion of genetic variation that aids in rapid evolutionary responses to environmental challenges. (© The Author(s) 2023. Published by Oxford University Press on behalf of The American Genetic Association. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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