Is the presence of Merkel cell polyomavirus and human papillomavirus DNA in keratinocyte cancers and precancers associated with HIV status? A case-control study.

Autor:	Goolamali SI; Dermatology Department, Chelsea and Westminster Hospital, London, UK., Shim TN; Dermatology Department, Chelsea and Westminster Hospital, London, UK., Purdie K; Blizard Institute, Queen Mary University of London, UK., Mladkova N; Blizard Institute, Queen Mary University of London, UK., Francis N; Histopathology Department, Imperial College, London, UK., Harwood CA; Blizard Institute, Queen Mary University of London, UK., Bunker CB; Dermatology Department, Chelsea and Westminster Hospital, London, UK.; Dermatology Department, University College Hospital, London, UK.
Jazyk:	angličtina
Zdroj:	Clinical and experimental dermatology [Clin Exp Dermatol] 2024 Feb 14; Vol. 49 (3), pp. 263-266.
DOI:	10.1093/ced/llad336
Abstrakt:	The epidemiology and potential pathogenic roles of human papillomavirus (HPV) and Merkel cell polyomavirus (MCV) in keratinocyte cancers (KCs) arising in people living with HIV (PLWH) compared with HIV-negative individuals are poorly understood. These issues were investigated by a case-control study in which the presence of MCV and HPV DNA was identified by polymerase chain reaction in microdissected formalin-fixed paraffin-embedded tissue from PLWH and HIV-negative individuals. The samples comprised 190 cutaneous and genital KCs/precancers (actinic keratoses, n = 43; cutaneous squamous cell carcinoma (cSCC) in situ, n = 24; basal cell carcinoma, n = 78; cSCC, n = 34; penile carcinoma in situ, n = 9; penile SCC, n = 2 from 104 individuals (PLWH, n = 51; HIV-negative, n = 53). Almost one-quarter of samples were positive for MCV: this was not significantly associated with either HIV status (P = 0.06) nor lesion type. Overall, 36% (16/44) of MCV-positive lesions were coinfected with HPV; this was also not associated with HIV status. These findings indicate that if these viruses do contribute to the pathogenesis of KCs, it is likely to be independent of HIV status. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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