Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors.

Autor:	Madalena IR; Universidade da Região de Joinville - UNIVILLE, Departamento de Odontologia, Joinville, Santa Catarina, Brasil.; Universidade de Uberaba - UNIUBE, Departamento de Biomateriais, Uberaba, Minas Gerais, Brasil.; Centro Universitário Presidente Tancredo de Almeida Neves - UNIPTAN, Faculdade de Odontologia, São João del Rei, Minas Gerais, Brasil., Reis CLB; Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Clínica Infantil, Ribeirão Preto, São Paulo, Brasil., Matsumoto MAN; Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Clínica Infantil, Ribeirão Preto, São Paulo, Brasil., Stuani MBS; Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Clínica Infantil, Ribeirão Preto, São Paulo, Brasil., Mattos NHR; Universidade Tuiuti do Paraná - UTP, Curitiba, Paraná, Brasil., Oliveira DSB; Universidade Federal de Alfenas, Faculdade de Odontologia, Departamento de Clínica e Cirurgia, Minas Gerais, Brasil., Oliveira MAHM; Universidade de Uberaba - UNIUBE, Departamento de Biomateriais, Uberaba, Minas Gerais, Brasil., Roskamp L; Universidade Tuiuti do Paraná - UTP, Curitiba, Paraná, Brasil., Küchler EC; Universidade de Uberaba - UNIUBE, Departamento de Biomateriais, Uberaba, Minas Gerais, Brasil.; Universidade Tuiuti do Paraná - UTP, Curitiba, Paraná, Brasil., Baratto-Filho F; Universidade da Região de Joinville - UNIVILLE, Departamento de Odontologia, Joinville, Santa Catarina, Brasil.; Universidade Tuiuti do Paraná - UTP, Curitiba, Paraná, Brasil.
Jazyk:	angličtina
Zdroj:	Journal of applied oral science : revista FOB [J Appl Oral Sci] 2023 Sep 25; Vol. 31, pp. e20230184. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI:	10.1590/1678-7757-2023-0184
Abstrakt:	Background: Genetic polymorphisms have been shown to influence several physiological traits, including dental and craniofacial characteristics. Understanding the clinical relevance of genetic polymorphisms in dental practice is crucial to personalize treatment plans and improve treatment outcomes. Objective: to evaluate the association between dental age and genetic polymorphisms in genes encoding estrogen receptors alpha and beta (ESR1 and ESR2, respectively) in a sample of Brazilian children. Methodology: This retrospective cross-sectional study was performed with children undergoing orthodontic treatment. Patients with syndromes, congenital anomalies, craniofacial deformities, under hormonal or systemic treatment, and with a previous history of facial trauma were excluded. Panoramic radiographs were used to assess dental age according to the Demirjian, Goldstein, and Tanner method. A delta [dental age-chronological age (DA-CA)] was obtained, which shows whether the patient tends to have a normal, delayed (negative values), or advanced (positive values) dental age. DNA isolated from buccal cells was used to genotype four genetic polymorphisms: rs9340799 (A>G) and rs2234693 (C>T), located in ESR1; and rs1256049 (C>T) and rs4986938 (C>T), located in ESR2. A statistical analysis was performed and values of p<0.05 indicated statistical difference. Results: A total of 79 patients were included, 44 (55.70%) girls and 35 (44.30%) boys. The Demirjian, Goldstein, and Tanner method, in general, overestimated patients' age by 0.75 years. There was no difference in the delta of dental age between the sexes (p>0.05). Genetic polymorphisms in ESR1 and ESR2 were not associated with dental age (p>0.05). Conclusion: The studied genetic polymorphisms in ESR1 and ESR2 were not associated with dental age in Brazilian children.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu