Relationship of Serum Vitamin D Levels With Diabetic Foot in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.

Autor:	Atoum MF; Department of Medical Laboratory Sciences, Faculty of Applied Health Sciences, The Hashemite University, Zarqa, Jordan., Al Shdaifat A; Department of Internal and Family Medicine, Faculty of Medicine, The Hashemite University, Zarqa, Jordan., Al Hourani H; Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan., Al Hyari M; Center of Diabetes and Endocrinology, Prince Hamza Hospital, Diabetic Center, Amman, Jordan., Zahran R; Center of Diabetes and Endocrinology, Prince Hamza Hospital, Diabetic Center, Amman, Jordan., Abu Shaikh H; Prince Hamza Hospital, Amman, Jordan.
Jazyk:	angličtina
Zdroj:	The international journal of lower extremity wounds [Int J Low Extrem Wounds] 2023 Oct 04, pp. 15347346231205641. Date of Electronic Publication: 2023 Oct 04.
DOI:	10.1177/15347346231205641
Abstrakt:	Background and aims: Diabetic foot is one of the most severe complications in patients with diabetes mellitus and has been linked to 25-OH-vitamin D status. This study aims to determine the prevalence of 25-OH-vitamin D deficiency and its association with diabetic foot. Methods: Patients with type 2 diabetes mellitus were enrolled in this study. The patients were divided into the diabetic foot group (n = 95) and the non-diabetic foot group (n = 388). Weight, height, and waist circumference were measured. The 25-OH-vitamin D and the other biochemical tests were extracted from the electronic medical records. The difference in clinical parameters between the diabetic foot group and the non-diabetic foot group was analyzed, and the risk factors of the diabetic foot group were analyzed using logistic regression. Results: The prevalence of 25-OH-vitamin D deficiency was 44.6%, accounting for 57.9% of all the diabetic foot group patients and only 41.0% of the non-diabetic foot group patients. The mean serum 25-OH-vitamin D level was significantly different between the diabetic foot group and the non-diabetic foot group (19.8 ± 9.5 vs 24.1 ± 11.8; P  = .011). Serum 25-OH-vitamin D and B12 were found to have a significant positive correlation ( r  = 0.410, P  = <.01). The 25-OH-vitamin D level and body mass index were independently associated with diabetic foot ( P  = .043, OR = 1.21; P  = .009, OR =  1.47), respectively. Conclusions: The 25-OH-vitamin D deficiency was higher in the diabetic foot group. More research is needed to understand the role of 25-OH-vitamin D in the development of diabetic foot. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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