UDock2: interactive real-time multi-body protein-protein docking software.

Autor:	Plateau-Holleville C; XLIM, UMR CNRS 7252, University of Limoges, 87000 Limoges, France., Guionnière S; Laboratoire GBCM, EA 7528, Conservatoire National des Arts et Métiers, Hésam Université, 75003 Paris, France., Boyer B; Laboratoire GBCM, EA 7528, Conservatoire National des Arts et Métiers, Hésam Université, 75003 Paris, France., Jiménez-Garcia B; Zymvol Biomodeling, 08010 Barcelona, Spain., Levieux G; CEDRIC, EA 4626, Conservatoire National des Arts et Métiers, Hésam Université, 75003 Paris, France., Mérillou S; XLIM, UMR CNRS 7252, University of Limoges, 87000 Limoges, France., Maria M; XLIM, UMR CNRS 7252, University of Limoges, 87000 Limoges, France., Montes M; Laboratoire GBCM, EA 7528, Conservatoire National des Arts et Métiers, Hésam Université, 75003 Paris, France.; Institut Universitaire de France (IUF), Paris 75005, France.
Jazyk:	angličtina
Zdroj:	Bioinformatics (Oxford, England) [Bioinformatics] 2022 Jan 01; Vol. 39 (10).
DOI:	10.1093/bioinformatics/btad609
Abstrakt:	Motivation: Protein-protein docking aims at predicting the geometry of protein interactions to gain insights into the mechanisms underlying these processes and develop new strategies for drug discovery. Interactive and user-oriented manipulation tools can support this task complementary to automated software. Results: This article presents an interactive multi-body protein-protein docking software, UDock2, designed for research but also usable for teaching and popularization of science purposes due to its high usability. In UDock2, the users tackle the conformational space of protein interfaces using an intuitive real-time docking procedure with on-the-fly scoring. UDock2 integrates traditional computer graphics methods to facilitate the visualization and to provide better insight into protein surfaces, interfaces, and properties. Availability and Implementation: UDock2 is open-source, cross-platform (Windows and Linux), and available at http://udock.fr. The code can be accessed at https://gitlab.com/Udock/Udock2. (© The Author(s) 2023. Published by Oxford University Press.)
Databáze:	MEDLINE
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