What do we know about the function of SARS-CoV-2 proteins?

Autor:	Justo Arevalo S; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru.; Departmento de Bioquimica, Instituto de Quimica, Universidade de São Paulo, São Paulo, Brazil., Castillo-Chávez A; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru., Uribe Calampa CS; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru., Zapata Sifuentes D; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru.; Departmento de Bioquimica, Instituto de Quimica, Universidade de São Paulo, São Paulo, Brazil., Huallpa CJ; Facultad de Ciencias, Universidad Nacional Agraria La Molina, Lima, Peru., Landa Bianchi G; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru., Garavito-Salini Casas R; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru., Quiñones Aguilar M; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru., Pineda Chavarría R; Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Sep 18; Vol. 14, pp. 1249607. Date of Electronic Publication: 2023 Sep 18 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1249607
Abstrakt:	The COVID-19 pandemic has highlighted the importance in the understanding of the biology of SARS-CoV-2. After more than two years since the first report of COVID-19, it remains crucial to continue studying how SARS-CoV-2 proteins interact with the host metabolism to cause COVID-19. In this review, we summarize the findings regarding the functions of the 16 non-structural, 6 accessory and 4 structural SARS-CoV-2 proteins. We place less emphasis on the spike protein, which has been the subject of several recent reviews. Furthermore, comprehensive reviews about COVID-19 therapeutic have been also published. Therefore, we do not delve into details on these topics; instead we direct the readers to those other reviews. To avoid confusions with what we know about proteins from other coronaviruses, we exclusively report findings that have been experimentally confirmed in SARS-CoV-2. We have identified host mechanisms that appear to be the primary targets of SARS-CoV-2 proteins, including gene expression and immune response pathways such as ribosome translation, JAK/STAT, RIG-1/MDA5 and NF-kβ pathways. Additionally, we emphasize the multiple functions exhibited by SARS-CoV-2 proteins, along with the limited information available for some of these proteins. Our aim with this review is to assist researchers and contribute to the ongoing comprehension of SARS-CoV-2's pathogenesis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Justo Arevalo, Castillo-Chávez, Uribe Calampa, Zapata Sifuentes, Huallpa, Landa Bianchi, Garavito-Salini Casas, Quiñones Aguilar and Pineda Chavarría.)
Databáze:	MEDLINE
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