Smaller and Denser Speech Graphs in Nondemented Patients with Progressive Supranuclear Palsy.

Autor: Ma J; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China., Zhang G; China Institute of Sport Science, Beijing, China., Sun X; Department of Neurology, Weifang People's Hospital, Weifang, China., Chan P; Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China., Ye Z; Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Jazyk: angličtina
Zdroj: Behavioural neurology [Behav Neurol] 2023 Sep 25; Vol. 2023, pp. 3771601. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI: 10.1155/2023/3771601
Abstrakt: The well-established semantic fluency test measures the ability to produce a sequence of spoken words from a particular category within a limited period of time. Like patients with Parkinson's disease (PD), patients with progressive supranuclear palsy (PSP) tend to produce fewer correct words than age-matched healthy adults. This study further examined the difference between patients with PSP and PD in their semantic fluency performance using a graph theory-based approach. Twenty-nine patients with PSP Richardson's syndrome (PSP-RS), thirty-eight patients with PD, and fifty-one healthy controls (HC) were recruited. All participants completed a standard semantic fluency test (animals). Their verbal responses were recorded, transcripted, and transformed into directed speech graphs. The speech graphs of the PSP-RS group showed higher density, shorter diameter, and shorter average shortest path than those of the PD and HC groups. It indicates that the PSP-RS group produced smaller and denser speech graphs than the PD and HC groups. In the PSP-RS group, moreover, the average shortest paths of the speech graphs correlated with the severity of motor symptoms. This study shows the potential of the graph theory-based approach in distinguishing the semantic fluency performance of nondemented patients with PSP-RS and PD.
Competing Interests: The authors declared no conflict of interest.
(Copyright © 2023 Jinghong Ma et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje