Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD.

Autor:	Künzel SH; Department of Ophthalmology, University of Bonn, Bonn, Germany., Broadbent E; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, 65 North Mario Capecchi Drive, Salt Lake City, 84312, UT, United States., Möller PT; Department of Ophthalmology, University of Bonn, Bonn, Germany., Lindner M; Institute of Physiology and Pathophysiology, Department of Neurophysiology, Philipps University, Deutschhausstr. 1-2, Marburg 35037, Germany.; Nuffield Laboratory of Ophthalmology, Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Goerdt L; Department of Ophthalmology, University of Bonn, Bonn, Germany., Czauderna J; Department of Ophthalmology, University of Bonn, Bonn, Germany., Schmitz-Valckenberg S; Department of Ophthalmology, University of Bonn, Bonn, Germany.; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, 65 North Mario Capecchi Drive, Salt Lake City, 84312, UT, United States., Holz FG; Department of Ophthalmology, University of Bonn, Bonn, Germany., Pfau M; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland., Fleckenstein M; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, 65 North Mario Capecchi Drive, Salt Lake City, 84312, UT, United States.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2023 Sep 23. Date of Electronic Publication: 2023 Sep 23.
DOI:	10.1101/2023.09.22.23295946
Abstrakt:	Background/aims: The primary objective was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Methods: This prospective, non-interventional, natural-history 'Directional Spread in Geographic-Atrophy' study was conducted at the University Eye Hospital in Bonn, enrolling 82 patients with bilateral GA. Parameters such as GA location (assessed by the Early Treatment Diabetic Retinopathy Study grid), best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), reading acuity, and speed were examined. The association between these parameters and VRQoL, as gauged using the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25), was analyzed through least absolute shrinkage and selection operator with linear mixed-effects models. Results: The average total GA area observed was 2.9 ± 1.2 mm 2 (better eye) and 3.1 ± 1.3 mm 2 (worse eye). The VRQoL scores for distance and near activities were most associated with the inner lower and inner left subfields of the better eye. For foveal-sparing patients, the LLVA of the better eye was the predominant determinate impacting all VRQoL scales. Conclusion: GA location, specifically the inner lower and inner left subfields of the better eye, has a notable effect on VRQoL in GA patients. LLVA stands out as especially vital in foveal-sparing patients, underscoring the importance for clinicians to incorporate considerations of GA location and functional parameters into their risk-benefit assessments for emerging treatments. Competing Interests: Conflict of Interest: no conflicting relationship exists for any author
Databáze:	MEDLINE
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