Tubal superfetation following frozen-thawed single-embryo transfers in two separate cycles: Case report and literature review.

Autor: Ohana E; Department of Obstetrics and Gynecology, Soroka University Medical Center, Beer Sheva, Israel.; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel., Samueli B; Department of Pathology, Soroka University Medical Center, Beer Sheva, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel., Shahar M; Department of Obstetrics and Gynecology, Soroka University Medical Center, Beer Sheva, Israel.; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel., Ben-Haroush A; Infertility and IVF Unit, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Shufaro Y; Infertility and IVF Unit, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2024 May; Vol. 165 (2), pp. 562-565. Date of Electronic Publication: 2023 Oct 03.
DOI: 10.1002/ijgo.15170
Abstrakt: Superfetation is a very rare occurrence. In the context of assisted reproduction, it has been reported only as an intrauterine pregnancy after ovarian stimulation and/or embryo transfer in the presence of an undiagnosed ectopic pregnancy. Here we report a case of a 27-year-old anovulatory patient, gravida 1 para 1, who underwent two frozen-thawed single-blastocyst transfers in separate cycles. The patient reported that 12 days after the first transfer, she had menstrual bleeding and stopped her estradiol and progesterone supplementation without undergoing a blood human chorionic gonadotropin (βhCG) test. At her request, a second cycle was immediately initiated, with endometrial thickness measuring 4 mm. Eleven days after the second transfer, the βhCG value was inappropriately high. A right tubal pregnancy corresponding to 8 gestational weeks was diagnosed. Laparoscopy revealed a prominent right tubal pregnancy in addition to a significantly smaller left tubal pregnancy. The discordant tubal pregnancies were confirmed histologically. To our knowledge, superfetation involving a second ectopic pregnancy coexistent with a first, contralateral ectopic pregnancy consequent to consecutive in vitro fertilization procedures has not previously been described in the medical literature. This case emphasizes the importance of routine βhCG testing after every IVF cycle, even if apparently unsuccessful.
(© 2023 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.)
Databáze: MEDLINE
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