82 Rb and [ 15 O]H 2 O myocardial perfusion PET imaging: a prospective head to head comparison.

Autor: Krakauer M; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Ismail A; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Talleruphuus U; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Henriksen AC; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Lonsdale MN; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Rasmussen IL; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Fuglsang S; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Prescott E; Department of Cardiology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hovind P; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Marner L; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark. lisbeth.marner@regionh.dk.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. lisbeth.marner@regionh.dk.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2023 Dec; Vol. 30 (6), pp. 2790-2802. Date of Electronic Publication: 2023 Oct 03.
DOI: 10.1007/s12350-023-03372-7
Abstrakt: Background: 82 Rb PET and [ 15 O]H 2 O PET are both validated tracers for myocardical perfusion imaging but have not previously been compared clinically. During our site's transition from 82 Rb to [ 15 O]H 2 O PET, we performed a head-to-head comparison in a mixed population with suspected ischemic heart disease.
Methods: A total of 37 patients referred for perfusion imaging due to suspicion of coronary stenosis were examined with both 82 Rb and [ 15 O]H 2 O PET on the same day in rest and during adenosine-induced stress. The exams were rated by two blinded readers as normal, regional ischemia, globally reduced myocardial perfusion, or myocardial scarring. For [ 15 O]H 2 O PET, regional ischemia was defined as two neighboring segments with average stress perfusion ≤ 2.3 mL/(min·g). Further, we evaluated a total perfusion deficit (TPD) of ≥ 10% as a more conservative marker of ischemia.
Results: [ 15 O]H 2 O PET identified more patients with regional ischemia: 17(46%) vs 9(24%), agreement: 59% corresponding to a Cohen's kappa of .31 [95%CI .08-.53], (P < .001). Using the more conservative TPD ≥ 10%, the agreement increased to 86% corresponding to a kappa of .62 [95%CI .33-.92], (P = .001). For the subgroup of patients with no known heart disease (n = 18), the agreement was 94%. Interrater agreement was 95% corresponding to a kappa of .89 [95%CI .74-1.00] (P < .001).
Conclusions: In clinical transition from 82 Rb to [ 15 O]H 2 O PET, it is important to take into account the higher frequency of patients with regional ischemia detected by [ 15 O]H 2 O PET.
(© 2023. The Author(s).)
Databáze: MEDLINE
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