Identifying phenolics by UPLC-MS/MS in some Prangos Lindl. species and α-glucosidase inhibitory activities.

Autor: Onder A; Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara 06100, Türkiye. Electronic address: pharmacogalev@gmail.com., Gülmez N; Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara 06100, Türkiye; Ankara University, Institute of Health Sciences, Ankara, Türkiye., Baran MY; University of Health Sciences, Gülhane Faculty of Pharmacy, Department of Pharmacognosy, Ankara 06108, Türkiye., Kuruuzum-Uz A; Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara 06100, Türkiye., Trendafilova A; Bulgarian Academy of Sciences, Institute of Organic Chemistry with Centre of Phytochemistry, 1113, Bulgaria., Cinar Koc AS; Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara 06100, Türkiye; Ankara University, Institute of Health Sciences, Ankara, Türkiye; Lokman Hekim University, Faculty of Pharmacy, Department of Pharmacognosy and Pharmaceutical Botany, Ankara 06510, Türkiye., Cakir O; Dicle University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Diyarbakır, Türkiye., Yilmaz MA; Dicle University, Faculty of Pharmacy, Department of Analytical Chemistry, Diyarbakır, Türkiye.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2023 Nov 30; Vol. 236, pp. 115733. Date of Electronic Publication: 2023 Sep 21.
DOI: 10.1016/j.jpba.2023.115733
Abstrakt: Diabetes mellitus is a chronic metabolic disorder associated with biochemical, physiological, and pathological changes in the liver and characterized by some deficiencies in insulin secretion or insulin action. Prangos Lindl. species are important plants used as spice and medicine in Asian countries, including Türkiye. This study first aimed to evaluate the antidiabetic potential of the aerial parts of the 5 different Prangos species (Apiaceae) collected from various locations to discover and identify bioactive phenolic components. The results revealed that the methanolic extract of P. heyniae exhibited the highest activity against α-glucosidase inhibition compared to the other Prangos species (IC 50 = 458.54 ± 5.62 μg/mL). For this reason, the active species P. heyniae (an endemic species) was subjected to UPLC-MS/MS to evaluate the possible active phenolic components. The results showed that 53 phenolic compounds were correctly screened, 21 were precisely determined by UPLC-MS/MS in P. heyniae. Therefore, it was concluded that the aerial parts of P. heyniae might have therapeutic potential for hyperglycemia due to its phenolic compounds. Moreover, quinic acid (3.66%), chlorogenic acid (2.35%), rutin (2.96%), and hesperidin (0.79%) might be potential markers of the methanolic extract of P. heyniae. In the end, this study provides comprehensive knowledge regarding the phenolic profile of P. heyniae related to antidiabetic activity for the first time in this study.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Alev Onder reports financial support was provided by Ankara University, Scientific Research Projects Coordination Unit.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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