Does prior exposure to larvicides influence dengue virus susceptibility in Aedes aegypti (Diptera: Culicidae)?

Autor:	Aldridge RL; United States Department of Agriculture, Agricultural Research Service, Center for Medical, Agricultural, and Veterinary Entomology, 1600 SW 23rd Drive, Gainesville, FL 32608, USA., Alto BW; Entomology and Nematology Department, University of Florida, Florida Medical Entomology Laboratory, 200 9th Street S.E., Vero Beach, FL 32962, USA., Roxanne Connelly C; Centers for Disease Control and Prevention, 3156 Rampart Road, Ft. Collins, CO 80521, USA., Okech B; School of Medicine, Uniformed Service University of the Health Sciences, Bethesda, MD 20814, USA., Siegfried B; Pennsylvania Agricultural Experiment Station, Pennsylvania State University, University Park, PA 16802, USA., Eastmond BH; Entomology and Nematology Department, University of Florida, Florida Medical Entomology Laboratory, 200 9th Street S.E., Vero Beach, FL 32962, USA., Alomar AA; Entomology and Nematology Department, University of Florida, Florida Medical Entomology Laboratory, 200 9th Street S.E., Vero Beach, FL 32962, USA., Linthicum KJ; United States Department of Agriculture, Agricultural Research Service, Center for Medical, Agricultural, and Veterinary Entomology, 1600 SW 23rd Drive, Gainesville, FL 32608, USA.
Jazyk:	angličtina
Zdroj:	Journal of medical entomology [J Med Entomol] 2024 Jan 12; Vol. 61 (1), pp. 166-174.
DOI:	10.1093/jme/tjad137
Abstrakt:	Control of mosquito vector populations is primarily intended to reduce the transmission of pathogens they transmit. Use of chemical controls, such as larvicides, can have unforeseen consequences on adult traits if not applied properly. The consequences of under application of larvicides are little studied, specifically the impacts on pathogen infection and transmission by the vectors that survive exposure to larvicides. We compared vector susceptibility of Aedes aegypti (L.) for dengue virus, serotype 1 (DENV-1) previously exposed as larvae to an LC50 of different classes of insecticides as formulated larvicides. Larval exposure to insect growth regulators (methoprene and pyriproxyfen) significantly increased susceptibility to infection of DENV-1 in Ae. aegypti adults but did not alter disseminated infection or transmission. Larval exposure to temephos, spinosad, and Bti did not increase infection, disseminated infection, or transmission of DENV-1. Our findings describe a previously under observed phenomenon, the latent effects of select larvicides on mosquito vector susceptibility for arboviruses. These data suggest that there are unintended consequences of sublethal exposure to select larvicides that can influence susceptibility of Ae. aegypti to DENV infection, and indicates the need for further investigation of sublethal effects of insecticides on other aspects of mosquito biology, especially those parameters relevant to a mosquitoes ability to transmit arboviruses (life span, biting behavior, extrinsic incubation period). (Published by Oxford University Press on behalf of Entomological Society of America 2023.)
Databáze:	MEDLINE
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