Towards Precision Ecotoxicology: Leveraging Evolutionary Conservation of Pharmaceutical and Personal Care Product Targets to Understand Adverse Outcomes Across Species and Life Stages.

Autor: Brooks BW; Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Institute of Biomedical Studies, Baylor University, Waco, Texas, USA., van den Berg S; Wageningen Environmental Research, Wageningen, The Netherlands., Dreier DA; Syngenta Crop Protection, Greensboro, North Carolina, USA., LaLone CA; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota., Owen SF; Global Sustainability, Astra Zeneca, Macclesfield, Cheshire, UK., Raimondo S; Gulf Ecosystem Measurement and Modeling Division, Office of Research and Development, US Environmental Protection Agency, Gulf Breeze, Florida., Zhang X; School of the Environment, Nanjing University, Nanjing, China.
Jazyk: angličtina
Zdroj: Environmental toxicology and chemistry [Environ Toxicol Chem] 2024 Mar; Vol. 43 (3), pp. 526-536. Date of Electronic Publication: 2023 Nov 03.
DOI: 10.1002/etc.5754
Abstrakt: Translation of environmental science to the practice aims to protect biodiversity and ecosystem services, and our future ability to do so relies on the development of a precision ecotoxicology approach wherein we leverage the genetics and informatics of species to better understand and manage the risks of global pollution. A little over a decade ago, a workshop focusing on the risks of pharmaceuticals and personal care products (PPCPs) in the environment identified a priority research question, "What can be learned about the evolutionary conservation of PPCP targets across species and life stages in the context of potential adverse outcomes and effects?" We review the activities in this area over the past decade, consider prospects of more recent developments, and identify future research needs to develop next-generation approaches for PPCPs and other global chemicals and waste challenges. Environ Toxicol Chem 2024;43:526-536. © 2023 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
(© 2023 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)
Databáze: MEDLINE
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