Mixed representations of sound and action in the auditory midbrain.

Autor:	Quass GL; Kresge Hearing Research Institute, Department of Otolaryngology - Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Rogalla MM; Kresge Hearing Research Institute, Department of Otolaryngology - Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Ford AN; Kresge Hearing Research Institute, Department of Otolaryngology - Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Apostolides PF; Kresge Hearing Research Institute, Department of Otolaryngology - Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 19. Date of Electronic Publication: 2023 Sep 19.
DOI:	10.1101/2023.09.19.558449
Abstrakt:	Linking sensory input and its consequences is a fundamental brain operation. Accordingly, neural activity of neo-cortical and limbic systems often reflects dynamic combinations of sensory and behaviorally relevant variables, and these "mixed representations" are suggested to be important for perception, learning, and plasticity. However, the extent to which such integrative computations might occur in brain regions upstream of the forebrain is less clear. Here, we conduct cellular-resolution 2-photon Ca 2+ imaging in the superficial "shell" layers of the inferior colliculus (IC), as head-fixed mice of either sex perform a reward-based psychometric auditory task. We find that the activity of individual shell IC neurons jointly reflects auditory cues and mice's actions, such that trajectories of neural population activity diverge depending on mice's behavioral choice. Consequently, simple classifier models trained on shell IC neuron activity can predict trial-by-trial outcomes, even when training data are restricted to neural activity occurring prior to mice's instrumental actions. Thus in behaving animals, auditory midbrain neurons transmit a population code that reflects a joint representation of sound and action. Competing Interests: Conflict of Interest Statement: The authors declare no conflict of interest.
Databáze:	MEDLINE
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