Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military APOE ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.

Autor:	Nkiliza A; Roskamp Institute, Sarasota, Florida, USA.; James A. Haley VA Hospital, Tampa, Florida, USA., Huguenard CJC; Roskamp Institute, Sarasota, Florida, USA.; Open University, Milton Keynes, United Kingdom., Aldrich GJ; Roskamp Institute, Sarasota, Florida, USA., Ferguson S; Roskamp Institute, Sarasota, Florida, USA.; Open University, Milton Keynes, United Kingdom., Cseresznye A; Roskamp Institute, Sarasota, Florida, USA., Darcey T; Roskamp Institute, Sarasota, Florida, USA., Evans JE; Roskamp Institute, Sarasota, Florida, USA., Dretsch M; U.S. Army Medical Research Directorate-West, Walter Reed Army Institute of Research, Joint Base Lewis-McChord, Washington, USA.; U.S. Army Aeromedical Research Laboratory, Fort Novosel, Alabama, USA., Mullan M; Roskamp Institute, Sarasota, Florida, USA.; James A. Haley VA Hospital, Tampa, Florida, USA., Crawford F; Roskamp Institute, Sarasota, Florida, USA.; Open University, Milton Keynes, United Kingdom.; James A. Haley VA Hospital, Tampa, Florida, USA., Abdullah L; Roskamp Institute, Sarasota, Florida, USA.; Open University, Milton Keynes, United Kingdom.; James A. Haley VA Hospital, Tampa, Florida, USA.
Jazyk:	angličtina
Zdroj:	Neurotrauma reports [Neurotrauma Rep] 2023 Sep 25; Vol. 4 (1), pp. 643-654. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI:	10.1089/neur.2023.0045
Abstrakt:	Currently approved blood biomarkers detect intracranial lesions in adult patients with mild to moderate traumatic brain injury (TBI) acutely post-injury. However, blood biomarkers are still needed to help with a differential diagnosis of mild TBI (mTBI) and post-traumatic stress disorder (PTSD) at chronic post-injury time points. Owing to the association between phospholipid (PL) dysfunction and chronic consequences of TBI, we hypothesized that examining bioactive PL metabolites (oxylipins and ethanolamides) would help identify long-term lipid changes associated with mTBI and PTSD. Lipid extracts of plasma from active-duty soldiers deployed to the Iraq/Afghanistan wars (control = 52, mTBI = 21, PTSD = 34, and TBI + PTSD = 13) were subjected to liquid chromatography/mass spectrometry analysis to examine oxylipins and ethanolamides. Linear regression analyses followed by post hoc comparisons were performed to assess the association of these lipids with diagnostic classifications. Significant differences were found in oxylipins derived from arachidonic acid (AA) between controls and mTBI, PTSD, and mTBI + PTSD groups. Levels of AA-derived oxylipins through the cytochrome P450 pathways and anandamide were significantly elevated among mTBI + PTSD patients who were carriers of the apolipoprotein E E4 allele. These studies demonstrate that AA-derived oxylipins and anandamide may be unique blood biomarkers of PTSD and mTBI + PTSD. Further, these AA metabolites may be indicative of an underlying inflammatory process that warrants further investigation. Future validation studies in larger cohorts are required to determine a potential application of this approach in providing a differential diagnosis of mTBI and PTSD in a clinical setting. Competing Interests: No competing financial interests exist. (© Aurore Nkiliza et al., 2023; Published by Mary Ann Liebert, Inc.)
Databáze:	MEDLINE
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