Serum inflammation and oxidative DNA damage amelioration in cocks-fed supplemental Vernonia amygdalina and zinc in aflatoxin B 1 contaminated diets.

Autor: Olarotimi OJ; Department of Animal Science, Faculty of Agriculture, Adekunle Ajasin University, Akungba-Akoko, 342111 Ondo State, Nigeria., Gbore FA; Department of Animal Science, Faculty of Agriculture, Adekunle Ajasin University, Akungba-Akoko, 342111 Ondo State, Nigeria., Oloruntola OD; Department of Animal Science, Faculty of Agriculture, Adekunle Ajasin University, Akungba-Akoko, 342111 Ondo State, Nigeria., Jimoh OA; Department of Agricultural Technology, The Federal Polytechnic, Ado-Ekiti, 360231 Ekiti State, Nigeria.
Jazyk: angličtina
Zdroj: Translational animal science [Transl Anim Sci] 2023 Sep 16; Vol. 7 (1), pp. txad113. Date of Electronic Publication: 2023 Sep 16 (Print Publication: 2023).
DOI: 10.1093/tas/txad113
Abstrakt: The objective of the study was to assess the comparative effects of Vernonia amygdalina leaf meal ( VALM ) and zinc ( Zn ) on the serum proinflammatory and anti-inflammatory cytokines as well as DNA damage of cocks-fed aflatoxin B 1 ( AFB 1 ) contaminated diets. A total of 250 sexually mature Isa White cocks of 24 weeks old were randomly distributed into five groups (treatments) with each containing 50 birds, which was replicated five times with 10 birds per replicate. Cocks in group A were fed basal diet only, group B was fed basal diet contaminated with 1 mg AFB 1 /kg diet, group C received diet B (basal + 1 mg/kg AFB 1 ) with 50 mg/kg Zn, group D was fed diet B with 2.5 g/kg VALM, and group E received diet B with 5.0 g/kg VALM, respectively. Feed and water were supplied ad libitum with fresh feed added to the feed troughs at 6:00 a.m. and 6:00 p.m., respectively. While serum tumor necrosis factor-alpha ( TNF-α ), interleukin 1 beta ( IL-1β ), 8-hydroxy-2'-deoxyguanosine ( 8-OHdG ), and nuclear factor kappa B ( NF-κB ) were significantly ( P  < 0.05) elevated among the cocks on diet B, significant ( P  < 0.05) reductions were recorded among cocks on diets C, D, and E. Conversely, birds in group B had significant ( P  < 0.05) depression in serum interleukin 4 ( IL-4 ) and interleukin 10 ( IL-10 ) while improvements ( P  < 0.05) were recorded among cocks in groups C, D, and E, respectively. Therefore, the inclusion of VALM offset the adverse physiological effects of AFB 1 observed among group B birds. The effects were comparable with the results presented by the cocksfed diet containing Zn.
Competing Interests: None declared.
(© The Author(s) 2023. Published by Oxford University Press on behalf of the American Society of Animal Science.)
Databáze: MEDLINE
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