Use of Diuretics and Risk of Acute Angle Closure: A Case-Control Study.
| Autor: | Qiao GL; Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada., Mikelberg FS; Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada., Etminan M; Departments of Ophthalmology and Visual Sciences, Medicine and Pharmacology, University of British Columbia, Vancouver, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | Ophthalmic epidemiology [Ophthalmic Epidemiol] 2024 Aug; Vol. 31 (4), pp. 321-324. Date of Electronic Publication: 2023 Oct 03. |
| DOI: | 10.1080/09286586.2023.2264387 |
| Abstrakt: | Purpose: To examine the possible link between acute angle closure (AAC) with use of diuretics. Methods: A nested case-control study (NCC) was conducted among a cohort of diuretic users using the PharMetrics Plus database from 2006 to 2020. Cases were identified as the first international classification of diseases 9 th and 10 th editions (ICD-9/10) code for ACC. For each case, 4 controls were selected and matched to the cases by age and sex using density-based sampling. A conditional logistic regression model was used to compute rate ratios (RRs) adjusted for the drugs topiramate, bupropion, sulphonamide antibiotics, acetazolamide, and sulfasalazine. The RRs for a negative control drug, amlodipine, was also assessed. Results: From the initial cohort of 713 574 diuretics users, 1 553 cases and 6 212 controls were identified. No increase in the risk of AAC with current users of diuretics was found (RR = 1.06, (95% CI: 0.81-1.37) for all diuretics; RR = 0.97, (95% CI: 0.71-1.32) for thiazides; RR = 1.24, (95% CI: 0.90-1.73) for loop diuretics; RR = 0.99, (95% CI: 0.73-1.36) for potassium sparing). Conclusion: We found no increase in the risk of acute angle closure with use of diuretics. Future studies are needed to confirm these findings. |
| Databáze: | MEDLINE |
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