Evaluation of Anaplasma spp. seroprevalence in dogs and association with incidence of human anaplasmosis.

Autor: Braff JC; IDEXX Laboratories, Inc., 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: jennifer-braff@idexx.com., Arguello-Marin A; IDEXX Laboratories, Inc., 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: andrea-arguello-marin@idexx.com., Hanscom J; IDEXX Laboratories, Inc., 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: jancy-hanscom@idexx.com., Saucier J; IDEXX Laboratories, Inc., 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: jill-saucier@idexx.com., Beall MJ; IDEXX Laboratories, Inc., 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: melissa-beall@idexx.com., Qurollo BA; College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, 11, Raleigh, NC 27606, USA. Electronic address: baquroll@ncsu.edu., Chandrashekar R; IDEXX Laboratories, Inc., 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: chandra-chandrashekar@idexx.com., Buch J; IDEXX Laboratories, Inc., 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: jesse-buch@idexx.com.
Jazyk: angličtina
Zdroj: Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2023 Oct; Vol. 45, pp. 100923. Date of Electronic Publication: 2023 Aug 24.
DOI: 10.1016/j.vprsr.2023.100923
Abstrakt: Point-of-care (POC) ELISA tests are routinely used in US veterinary practices to screen canine patients for antibodies to tick-transmitted pathogens. Results are also used to monitor spatial and temporal trends in canine seroprevalence, and these data can build awareness of the risk to humans of tick-transmitted diseases such as Lyme disease and anaplasmosis. This study utilized a second-generation test that has incorporated additional Anaplasma-specific peptides into a commercial POC ELISA test to allow detection of Anaplasma spp. antibodies earlier post-infection. A convenience population consisting of 19,894 canine samples from a US commercial diagnostic laboratory were tested using the second-generation POC ELISA test to describe regional Anaplasma spp. canine seroprevalence and assess correlation to anaplasmosis cases reported to Centers for Disease Control and Prevention by state. Antibodies to Anaplasma spp. were detected in 1646 samples (8.3%) with the Northeast and Midwest US census regions having the highest proportion of positive samples. At the state level, a significant correlation was found between canine Anaplasma spp. seroprevalence and human anaplasmosis incidence (r 2  = 0.64). Although estimates of canine Anaplasma spp. seroprevalence presented here using the second-generation POC ELISA are generally increased, especially in the Northeast and Midwest, the regional distribution of canine samples testing positive for Anaplasma spp. antibodies is consistent with previous reports. The observed correlation with human anaplasmosis incidence indicates that results from the second-generation POC ELISA will continue to add value in epidemiological assessment of human anaplasmosis risk.
Competing Interests: Declaration of Competing Interest Jennifer C. Braff reports a relationship with IDEXX Laboratories Inc. that includes: employment. Andrea Arguello-Marin reports a relationship with IDEXX Laboratories Inc. that includes: employment. Jancy Hanscom reports a relationship with IDEXX Laboratories Inc. that includes: employment. Jill Saucier reports a relationship with IDEXX Laboratories Inc. that includes: employment. Melissa J. Beall reports a relationship with IDEXX Laboratories Inc. that includes: employment. Ramaswamy Chandrashekar reports a relationship with IDEXX Laboratories Inc. that includes: employment. Jesse Buch reports a relationship with IDEXX Laboratories Inc. that includes: employment. Barbara A. Qurollo reports a relationship with IDEXX Laboratories Inc. that includes: funding grants.
(Copyright © 2023 IDEXX Laboratories, Inc. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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