Presynaptic glutamate receptors in nociception.

Autor: Xie RG; Department of Neurobiology, Fourth Military Medical University, Xi'an 710032, China. Electronic address: rgxie@fmmu.edu.cn., Xu GY; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou 215123, China., Wu SX; Department of Neurobiology, Fourth Military Medical University, Xi'an 710032, China. Electronic address: shengxi@fmmu.edu.cn., Luo C; Department of Neurobiology, Fourth Military Medical University, Xi'an 710032, China. Electronic address: luoceng@fmmu.edu.cn.
Jazyk: angličtina
Zdroj: Pharmacology & therapeutics [Pharmacol Ther] 2023 Nov; Vol. 251, pp. 108539. Date of Electronic Publication: 2023 Sep 30.
DOI: 10.1016/j.pharmthera.2023.108539
Abstrakt: Chronic pain is a frequent, distressing and poorly understood health problem. Plasticity of synaptic transmission in the nociceptive pathways after inflammation or injury is assumed to be an important cellular basis for chronic, pathological pain. Glutamate serves as the main excitatory neurotransmitter at key synapses in the somatosensory nociceptive pathways, in which it acts on both ionotropic and metabotropic glutamate receptors. Although conventionally postsynaptic, compelling anatomical and physiological evidence demonstrates the presence of presynaptic glutamate receptors in the nociceptive pathways. Presynaptic glutamate receptors play crucial roles in nociceptive synaptic transmission and plasticity. They modulate presynaptic neurotransmitter release and synaptic plasticity, which in turn regulates pain sensitization. In this review, we summarize the latest understanding of the expression of presynaptic glutamate receptors in the nociceptive pathways, and how they contribute to nociceptive information processing and pain hypersensitivity associated with inflammation / injury. We uncover the cellular and molecular mechanisms of presynaptic glutamate receptors in shaping synaptic transmission and plasticity to mediate pain chronicity, which may provide therapeutic approaches for treatment of chronic pain.
Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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