Prenatal risk factors and postnatal cannabis exposure: Assessing dual models of schizophrenia-like rodents.

Autor: Martín-Cuevas C; Instituto de Biomedicina de Sevilla (IBiS)/University Hospital Virgen del Rocío/CSIC/University of Sevilla, Manuel Siurot AV, 41013 Seville, Spain; Spanish Network for Research in Mental Health (CIBERSAM, ISCIII), Monforte de Lemos AV, 3-5, 28029 Madrid, Spain. Electronic address: cmartin21@us.es., Ramos-Herrero VD; Instituto de Biomedicina de Sevilla (IBiS)/University Hospital Virgen del Rocío/CSIC/University of Sevilla, Manuel Siurot AV, 41013 Seville, Spain. Electronic address: vramos-ibis@us.es., Crespo-Facorro B; Instituto de Biomedicina de Sevilla (IBiS)/University Hospital Virgen del Rocío/CSIC/University of Sevilla, Manuel Siurot AV, 41013 Seville, Spain; Spanish Network for Research in Mental Health (CIBERSAM, ISCIII), Monforte de Lemos AV, 3-5, 28029 Madrid, Spain; Department of Psychiatry, School of Medicine, University of Sevilla, Manuel Siurot AV, 41013 Seville, Spain. Electronic address: benedicto.crespo@unican.es., Sánchez-Hidalgo AC; Instituto de Biomedicina de Sevilla (IBiS)/University Hospital Virgen del Rocío/CSIC/University of Sevilla, Manuel Siurot AV, 41013 Seville, Spain; Spanish Network for Research in Mental Health (CIBERSAM, ISCIII), Monforte de Lemos AV, 3-5, 28029 Madrid, Spain. Electronic address: asanchez36@us.es.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2023 Nov; Vol. 154, pp. 105409. Date of Electronic Publication: 2023 Sep 30.
DOI: 10.1016/j.neubiorev.2023.105409
Abstrakt: Schizophrenia (SCZ) is a multifactorial neurodevelopmental disorder caused by genetic and environmental alterations, especially during prenatal stages. On the other hand, cannabis consumption in adolescence has been also linked to an increased risk of developing SCZ. The combination of both hits has been proposed as the dual hit hypothesis of SCZ. We systematically reviewed prenatal environmental alterations and cannabis consumption during adolescence that are associated with an increased risk of SCZ, following the PRISMA model. The analysis focused on dual animal models where the first hit is prenatal environmental exposure and the second hit consists of postnatal cannabis exposure. The articles were evaluated by three independent reviewers based on inclusion criteria. We extracted the first author´s name, year, model species, sex and analysis. The articles reported on dual murine models and their effects on weight, behavior, genetics, electrophysiology and brain structure and function. We conclude that the defects caused by the dual hits depend on the sex of the model, as well as type of hits.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing financial interests or personal relationships that could have influenced the work reported in this article.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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