| Autor: |
Wei QH; School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Zhang JP; School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Lu ZY; School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Jia XH; School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Zhao XD; School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Wang ZW; School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Wang XJ; School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China. |
| Abstrakt: |
Two new monoterpene indole alkaloids, Eleganine A ( 1 ) and Eleganine B ( 2 ), along with 11 known compounds (3-13) were isolated from the stems and leaves of Gelsemium elegans . Compound 1 is a gelsenicine-related monoterpenoid indole alkaloid possessing an iridoid unit. Their structures and absolute configurations of 1 - 2 were established by UV, IR, HR-ESI-MS, NMR spectroscopy, and electronic circular dichroism data analyses. All isolated compounds were evaluated for their anti-inflammatory and inhibiting glucose-induced mesanginal cell proliferation activities. None of them showed activity with IC 50 far beyond 50 μ M. |
