Martin's Formula As the Most Suitable Method for Estimation of Low-Density Lipoprotein Cholesterol in Indian Population.

Autor: Farheen F; Department of Chemical Pathology, USM KLE International Medical Programme, Belgaum, Karnataka, India., Ambiger S; Department of Biochemistry, KLE Academy of Higher Education and Research (KAHER), J.N. Medical College, Belagavi, Karnataka., Jaalam K; Department of Anaesthesia and Critical Care Medicine, School of Medical Science, PPSP USM Kubang Kerian, Malaysia, and Deputy Dean, USM KLE International Medical Programme, Belgaum, India., Javali S; Department of Community Medicine, USM KLE International Medical Programme, Belgaum, Karnataka, India.
Jazyk: angličtina
Zdroj: Journal of laboratory physicians [J Lab Physicians] 2023 Jul 13; Vol. 15 (4), pp. 545-551. Date of Electronic Publication: 2023 Jul 13 (Print Publication: 2023).
DOI: 10.1055/s-0043-1768951
Abstrakt: Background  Because of cost effectiveness, most of the laboratories in India estimate low-density lipoprotein cholesterol (LDL-C) levels with the Friedewald's formula. There were many shortcomings of the Friedewald's formula. Recently, Martin and colleagues have derived a new formula for calculating LDL-C. The present study was undertaken to calculate LDL-C using various formulae (Friedewald's formula, Anandaraja's formula, and Martin's formula) and to compare directly measured LDL-C (D-LDL-C) with calculated LDL-C at various ranges of triglyceride (TG) concentration. Materials and Methods  The present study compared LDL-C measured by Martin's formula, Friedewald's formula, and Anandaraja's formula with D-LDL-C in 280 outpatient fasting samples between the age groups of 18 and 50 years. Depending on the TG values, study samples were divided into four groups. Group 1: less than 200 mg/dL; Group 2: 200 to 300 mg/dL; Group 3: 300 to 400 mg/dL; and Group 4: more than 400 mg/dL. Results  Martin's formula shows highest correlation with r -value of 0.9979 compared with Friedewald's (0.9857) and Anandaraja's (0.9683) r -values. The mean difference was least for Martin's formula (0.31 ± 3.53) compared with other formulae. Among all the groups, percentage of error was least for Martin's formula (0.23%). Martin's LDL-C shows highest concordance (90.90%) compared with Friedewald's (79.60%) and Anandaraja's formulae (82.90%). Conclusion  Among all the groups, Martin's formula shows highest correlation, least percentage of error, highest concordance, and least mean differences. At all TG levels, Martin's formula is the best formula compared with the Friedewald's formula and Anandaraja's formula.
Competing Interests: Conflict of Interest None declared
(The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
Databáze: MEDLINE
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