TET3 plays a critical role in white adipose development and diet-induced remodeling.

Autor:	Jung BC; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., You D; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Lee I; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Li D; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Schill RL; Department of Molecular & Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MO, USA., Ma K; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Pi A; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Song Z; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Mu WC; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Wang T; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., MacDougald OA; Department of Molecular & Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MO, USA., Banks AS; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Kang S; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA. Electronic address: kangs@berkeley.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113196. Date of Electronic Publication: 2023 Sep 30.
DOI:	10.1016/j.celrep.2023.113196
Abstrakt:	Maintaining healthy adipose tissue is crucial for metabolic health, requiring a deeper understanding of adipocyte development and response to high-calorie diets. This study highlights the importance of TET3 during white adipose tissue (WAT) development and expansion. Selective depletion of Tet3 in adipose precursor cells (APCs) reduces adipogenesis, protects against diet-induced adipose expansion, and enhances whole-body metabolism. Transcriptomic analysis of wild-type and Tet3 knockout (KO) APCs unveiled TET3 target genes, including Pparg and several genes linked to the extracellular matrix, pivotal for adipogenesis and remodeling. DNA methylation profiling and functional studies underscore the importance of DNA demethylation in gene regulation. Remarkably, targeted DNA demethylation at the Pparg promoter restored its transcription. In conclusion, TET3 significantly governs adipogenesis and diet-induced adipose expansion by regulating key target genes in APCs. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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