PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging.

Autor: Ianni AM; Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. ianniam@upmc.edu.; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom. ianniam@upmc.edu.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. ianniam@upmc.edu., Eisenberg DP; Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Boorman ED; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom., Constantino SM; Department of Psychology, New York University, New York, NY, USA.; School of Public Policy and Urban Affairs, Northeastern University, Boston, MA, USA.; Department of Psychology, Northeastern University, Boston, MA, USA.; School of Public and International Affairs, Princeton University, Princeton, NJ, USA., Hegarty CE; Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Gregory MD; Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Masdeu JC; Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.; Houston Methodist Institute for Academic Medicine, Houston, TX, USA.; Weill Cornell Medicine, New York, NY, USA., Kohn PD; Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Behrens TE; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom., Berman KF; Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Sep 30; Vol. 14 (1), pp. 6122. Date of Electronic Publication: 2023 Sep 30.
DOI: 10.1038/s41467-023-41897-0
Abstrakt: Foraging behavior requires weighing costs of time to decide when to leave one reward patch to search for another. Computational and animal studies suggest that striatal dopamine is key to this process; however, the specific role of dopamine in foraging behavior in humans is not well characterized. We use positron emission tomography (PET) imaging to directly measure dopamine synthesis capacity and D 1 and D 2/3 receptor availability in 57 healthy adults who complete a computerized foraging task. Using voxelwise data and principal component analysis to identify patterns of variation across PET measures, we show that striatal D 1 and D 2/3 receptor availability and a pattern of mesolimbic and anterior cingulate cortex dopamine function are important for adjusting the threshold for leaving a patch to explore, with specific sensitivity to changes in travel time. These findings suggest a key role for dopamine in trading reward benefits against temporal costs to modulate behavioral adaptions to changes in the reward environment critical for foraging.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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